Formulation and Evaluation of Ondansetron Hydrochloride Sustained Release Tablets

Senthil Velavan, M (2008) Formulation and Evaluation of Ondansetron Hydrochloride Sustained Release Tablets. Masters thesis, Periyar College of Pharmaceutical Sciences for Girls, Tiruchirapalli.


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The main objective of this work is to investigate the possibility of sustained release dosage forms for the drug in ondansetron hydrochloride by usings different grades of HPMC polymers by diffusin controlled matrix. For this investigation in various formulation (formulation I-formulation –V )at different polymers for HPMC K4 M, HPMC K15 M, HPMC K100LVP were made by using drug 4 mg. The aim of this study to formulate and evaluate the release pattern of drug from sustained release matrix tablets. Hydro chloride as a sustained Release tablet dosage from for the treatment of cancer Chemotherapy in nausea and vomiting. Under, this, drug characterization and drug excipients interaction studies were carried out. The drug characterization showed satisfactory results. The physico chemical properties of the finished Poduct is complies with specifications. Ondansetron Hydrochloride SR tablets are formulated by using HPMC polymers in different concentrations. Five different formulations are formulated and evaluated. Only formulation five is better sustained release than compare with other formulation. Formulation five gives a release of 100.23 for an 12 hours. The prepared formulations are stable at or below 400C, hence it can be easily stored at room tempetature. This work concluding that has achieved the objectives of sustained release up to 12 hours.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Ondansetron; Hydrochloride; Sustained Release Tablets
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 25 Sep 2017 06:22
Last Modified: 25 Sep 2017 06:22

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