Gastro Retentive Drug Delivery System of Salbutamol Sulphate: Formulation and It’s in Vitro Evaluation

Narayanan, V (2008) Gastro Retentive Drug Delivery System of Salbutamol Sulphate: Formulation and It’s in Vitro Evaluation. Masters thesis, Periyar College of Pharmaceutical Sciences for Girls, Tiruchirapalli.


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Salbutamol sulphate is a short acting bronchodilators (β2 adrenergic agonist), which have short biological half -life about 2.7 - 5 hours. It is available as conventional oral tablets, solution, inhalation (inhaler, nebulised solution). The recommended dose of salbutamol in conventional dose 2 or 4 mg three or four times per day this project work is to develop the Salbutamol sulphate as Gastro Retentive Drug delivery System by Floating Matrix Tablets with extended drug release, for administration as once daily dose. Floating matrix tablets were formulated by different methods. Non-effervescent method- by using Hydrocolloids and Effervescent method - by using Gas-forming agents Thus, it is an object of the present invention to provide a Salbutamol as floating matrix tablets, which have gastro-retentive controlled oral drug delivery system. Several controlled oral drug delivery systems with prolonged gastric residence time have been reported such as Floating system, Swelling system, Mucoadhesive system, High density system and other gastric emptying systems have been commonly used. Floating system has a lower density than the gastric fluid and thus remains buoyancy in the stomach, which retain in the stomach for a prolonged period of time. The objective of this thesis work was planned to formulate the floating matrix tablet of Salbutamol sulphate by using different matrix forming material (like hydrophilic, hydrophobic and combined matrix forming material) with an extended drug release for administration as once daily dose. Hence this research work entitled “Gastro retentive Drug Delivery System of Salbutamol sulphate: Formulation and its in vitro Evaluation” was under taken with the above object to achieve. The hydrophilic floating matrix tablets were formulated by non-effervescent method by using different hydrocolloids like methyl cellulose, HPMC K100M, HPMC K4M and their floating properties and in vitro drug release were evaluated. In addition to the polymer stearic acid was included in the hydrophilic floating matrix tablet and the effects of stearic acid in the in vitro drug release were evaluated. From this study it was concluded that “Gastro retentive Drug Delivery Systems as Floating Matrix Tablets” designed as three different matrix tablet such as Hydrophilic Floating Matrix tablets, Insoluble Floating Matrix Tablets and Combined Floating Matrix Tablets among them the Hydrophilic Floating Matrix Tablets with stearic acid of hardness about 5kg/cm2 and round shaped tablets could be suitable for floating and controlled the drug release form the dosage form for administration as once daily dose.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Gastro Retentive Drug Delivery System; Salbutamol Sulphate; Vitro Evaluation
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 25 Sep 2017 06:19
Last Modified: 25 Sep 2017 06:19

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