Yuvaraju, J (2008) Preparation Characterization and Evaluation of Solid Dispersions of Aceclofenac - an Attempt to Develop Fast Release Formulations of Selected Solid Dispersion of Aceclofenac Tablets. Masters thesis, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore.
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Abstract
The present study aims at overcoming these problems by solid dispersion technology by using carriers like PVP-10, PVP-40, PVP-360 and PVA- 8136.With a view to develop fast release formulation of aceclofenac and hence improve its dissolution characteristics. Aceclofenac is an effective NSAID’s is practically insoluble in water. Where the dissolution is rate limiting. Studies were under taken on the preparation and evaluation of solid dispersions of aceclofenac with view to develop fast release formulation of aceclofenac. Four carriers viz PVP10, PVP40, PVP 360 and PVA 8136 were used to prepare the solid dispersions of aceclofenac by solvent evaporation and kneading method at various drug: carrier ratios namely (1:1, 1:3 and 1:9). The solid dispersions prepared were found to be fine and free flowing powders. X-ray diffraction studies revealed that crystalline nature of aceclofenac in pure form was reduced to amorphous form in the dispersions The thermal behavior of aceclofenac-PVP 40 solid dispersion was studied using DSC indicating that aceclofenac has complexed with PVP 40. This phenomenon is indicative of stronger interaction between aceclofenac and PVP 40 in the solid state. Interaction studies like TLC, FTIR indicated no interaction between drug and polymer used. Results of dissolution studies showed rapid and fast dissolution of aceclofenac from all solid dispersions when compare with pure drug and physical mixture. Good correlation was absorbed between percentage carrier in the solid dispersion and T50 and T90 values. Among the four carriers PVP 360 gave highest dissolution rate in the drug carrier ratio of 1:9. The order of dissolution of aceclofenac from various carriers is PVP 360(KM)>PVP40 (KM)> PVP10 (KM)> PVP40, PVA 8136 (KM)> PVP10, PVA8136 (KM), PVP360 (SE)> PVP10 (SE)> PVP10, PVA 8136 (SE), PVP40, PVA 8136 (SE)> PVP360, PVA 8136 (KM)> PVP40 (SE)> PVP360, PVA 8136 (SE) Aceclofenac solid dispersion in PVP 40 (1:9) was formulated into tablets with usual additives and the tablets were evaluated for dissolution characteristics .the dissolution of aceclofenac from tablet formulation based on solid dispersion was found to be fast and rapid when compared to physical mixture of drug and marketed tablet.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Aceclofenac Tablets; X-ray |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 25 Sep 2017 06:17 |
| Last Modified: | 25 Sep 2017 06:17 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3294 |
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