Design and Evaluation of Controlled Onset Extended Release (Coer) Press-Coated Tablets for Chronotherapeutic Delivery of Propranolol Hydrochloride

Yogasanthosh, G (2010) Design and Evaluation of Controlled Onset Extended Release (Coer) Press-Coated Tablets for Chronotherapeutic Delivery of Propranolol Hydrochloride. Masters thesis, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore.


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The present study to develop a chronotherapeutic delivery of propranolol Hcl in the form of press-coated tablets. Totally nine different press-coated tablets of propranolol Hcl were formulated by using various proportion of different polymers such as HPMC, ethyl cellulose, xanthan gum and guar gum by direct compression method. Here we selected propranolol Hcl as a drug candidate because of most commonly used in the treatment of hypertension, arrhythmia and angina pectoris. In this study we develop a chronological dosage form to release the drug in the early morning between 3a.m to 6a.m because renin, cortisol, angiotensin, aldosterone were secreted in peak level, most of the cardiovascular disorders such as angina pectoris, sudden cardiac death, stroke occurs in this time, the designed formulation was planned to taken at bedtime and the focus was to optimally deliver the drug in higher amounts in the early morning hours and lower amount at night. The prepared press-coated tablets (F1 to F9) were used for evaluation of compatibility studies, physico-chemical parameters such as hardness, friability, thickness, weight variation, content uniformity, in vitro release and in vitro release kinetics. The main focus of chronotherapeutic formulation of propranolol Hcl is to optimally deliver the drug in higher amounts in early morning hours (i.e. at time of greatest need) and lower amounts at night (i.e. when the need of drug is less). Because SBP and DBP rapidly rise in the early morning by at least 15 to 25 mm Hg and reach highest levels late in the day. Typically SBP and DBP decline in sleep by 10% to 20% from daytime. From the results it was concluded formulation F2 (EC:xanthan gum, 2:1) and F5 (EC:guar gum, 2:1) shows lag time of 5 hours consistent with requirement for chronotherapeutics and the drug release was extended as shown in fig 22 and 25. The best lag time could be achieved by higher the concentration of EC in outer shell. The lag time could also be controlled by altering the weight ratios and viscosity grade of polymers. Hence COER Propranolol Hcl tablets can provide a useful means for timed release and may be helpful for BP patients with morning surge, which results in better compliance by patients and fewer side effects. In conclusion, the time lag of press-coated tablet could be modulated by choosing the type and amount of excipient used in the outer shell to achieve the time-controlled disintegration according to the time required The present study indicated that the lag time of the press-coated tablet can be suitably modulated by formulating the outer shell with ethyl cellulose and xanthan gum or guar gum.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Press-Coated Tablets; Chronotherapeutic Delivery; Propranolol Hydrochloride
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 25 Sep 2017 06:16
Last Modified: 25 Sep 2017 06:16

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