Vahidha Banu, I (2008) Study on the Effect of Method of Addition of Papaya Pulp Powder as a Disintegrant in Tablet Formulation and its in Vitro Evaluation. Masters thesis, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore.
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Abstract
An attempt was made to study the use and the best method of incorporation of papaya pulp powder as a disintegrant in the formulation of paracetamol tablets. In order to find out the percentage and the best method of incorporation of the papaya pulp powder that could be used to formulate a product containing good disintegration and dissolution characteristics, different concentrations of the papaya pulp powder was used. Fifteen formulations were prepared with a natural disintegrant papaya pulp powder in the concentration of 2%, 4%, 6%, 8% and 10%. The papaya pulp powder is incorporated in the formulation by three methods. i.e. internal method, both internal and external method and external method. The tablets were evaluated and results were compared with each other. Among the formulated tablets it was found that F15 containing papaya pulp powder as external disintegrant showed good dissolution and disintegration characteristics. Although the disintegration and dissolution characteristics of the formulation containing papaya pulp powder as internal disintegrant were lower than the other formulation, they were within the limits specified in the pharmacopoeia. The results indicated that external method of incorporation of papaya pulp powder results in faster dissolution than internal and external method of incorporation which is in turn superior to internal method of incorporation. Its characteristics can further be improved by varying the concentration of papaya pulp powder.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Papaya Pulp Powder; Disintegrant; Tablet Formulation; Vitro Evaluation |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 25 Sep 2017 05:23 |
| Last Modified: | 25 Sep 2017 05:23 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3290 |
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