Raja Omar Sheriff, M (2008) Formulation and Evaluation of Transdermal Patches of Atorvastatin Calcium. Masters thesis, Sri Ramakrishna Institute of Paramedical Sciences.
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Abstract
The present study to develop transdermal therapeutic system for Atorvastatin calcium using polymers like HPMC, EC, and ERS100 was carried out for the purpose of attaining maximum bioavailability by tress passing pre-systemic hepatic metabolism. The compatibility studies using TLC and IR spectral studies revealed the absence of interaction between the drug and the polymer. The formulated patches were evaluated for the physico-chemical parameters, in vitro drug release studies, skin irritation studies and stability studies. The patches showed a significant variation in their average weight, which might be due to the variation in the proportions of polymers used. There was no significant change observed in the thickness of all the twentyone patches. The percentage moisture content and percentage moisture uptake is found to be high for the patches formulated with HPMC:EC when compared to the patches formulated with HPMC:ERS100 and EC:ERS100. The reason behind the screen might be the higher proportions of hydrophilic polymer, HPMC along with EC; whereas patches with HPMC:ERS100 combination shows lesser moisture content and moisture uptake because of the highly hydrophobic polymer, ERS100. For the patches with HPMC:EC tensile strength was found to be high and hardness was found to be low when compared to other patches which might be due to the nature of the polymers. All the patches showed uniform drug content. The formulations T8-T14 showed a better in vitro drug release profile across the cellulose membrane, when compared to the other formulations. This might be attributed to the nature of polymer; plasticizers used and even the permeation enhancer. The skin irritation studies using albino-rats revealed no signs of irritation or oedema, which confirms the skin compatibility of both the drug loaded and plain patches. As far the above results where concerned formulations T1, T8, and T15 where selected and subjected for stability studies at room temperature and at 40ºC for a period of 45 days. The stability studies results signified that the formulated patches possess adequate shelf life till 45 days. Since the results are encouraging for the formulation T8, the proper technique should be applied for commercial and mass production of the same formulation. However long term pharmacokinetic and pharmacodynamic studies should be undertaken to establish the usefulness of these patches.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Transdermal Patches; Atorvastatin Calcium |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 25 Sep 2017 06:13 |
| Last Modified: | 25 Sep 2017 06:13 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3283 |
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