The Study of the Expression of P53 and Ki-67 in Gastric Carcinomas and their Correlation with Clinico-Pathological Variables.

Hema, Vaneeswari (2012) The Study of the Expression of P53 and Ki-67 in Gastric Carcinomas and their Correlation with Clinico-Pathological Variables. Masters thesis, Madras Medical College, Chennai.

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Abstract

Gastric Cancer Is The Third Most Common Cancer In India And The Second Most Common Type Of Cancer Worldwide1. Approximately 800,000 New Cases Are Diagnosed Every Year, Despite A Steadily Declining Incidence Over The Previous 50 Years2. There Is Wide Variation In Incidence In Different Continents. The Highest Incidence Of Gastric Cancer Is In Asia3,4, Central Europe, And South America. There Have Also Been Changes Noted In The Topographic Distribution Of Gastric Cancer In Recent Years. The Incidence Of Proximal Gastric Tumors5,6 Has Been On The Rise. The Widespread Use Of Upper GI Endoscopy Has Led To More Frequent Detection Of Superficial Cancers. This Trend Has Had A Dramatic Impact On The Mortality Rate, To The Point That Gastric Cancer Is Now Considered Potentially Curable When Detected At An Early Stage7. Gastric Carcinoma Exhibits A Wide Range Of Morphological Phenotypes. The Histological Appearances Of Tumor Cannot Fully Reveal The Prognosis. The Prognosis Of Gastric Carcinoma Is Mainly Dependent On The Stage Of The Disease. Because Of The Variability Of Prognosis Within A Clinical Or Pathological Stage Of Gastric Cancer, There Has Been A Constant Search For Specific Biological Markers In Order To Identify Subgroups Of Patients With More Aggressive Course Of Disease8. The Immunohistochemical Protein Expression Of P53 And Ki-67 Has Been Proposed As A Potential Tool For The Evaluation Of The Biological Behavior Of Gastric Cancer9. Mutations Of The P53 Gene Have Been Found In A Number Of Malignancies10-17. In Contrast To The Normal P53 Protein, The Mutated P53 Protein Has An Increased Half-Life And Hence Accumulates Within The Cell Nucleus. This Can Be Detected Immunohistochemically Using Monoclonal Antibodies. Cell Proliferation Can Be Assessed By Immuno-Histochemical Staining With Proliferation Markers Such As Ki-67 Antigen. The Monoclonal Antibody MIB – 1 Reacts With Nuclear Antigen Present Throughout The Cell Cycle Of Proliferating Cells But Absent In Quiescent Cells18. The Level Of Ki 67 Immuno-Reactivity Correlates With The Degree Of Tumour Proliferation18. Patients Expressing High Levels Of P53 And Ki-67 Have Poorer Prognosis Because Of An Aggressive Tumour Behavior, Independent Of The Already Known Adverse Predictors. Thus The Routine Evaluation Of P53 And Ki -67 Could Be Useful In Identifying Patients With More Aggressive Disease And Contribute To A Better Therapeutic Approach. In This Study Of 50 Cases, An Attempt Is Made To Study The Expression Of P53 And Ki-67 Immunohistochemically And Compare It With Various Clinicopathological Parameters

Item Type: Thesis (Masters)
Uncontrolled Keywords: Expression P53; Ki-67 Gastric Carcinomas; Clinico-Pathological Variables;
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 23 Jun 2017 08:03
Last Modified: 23 Jun 2017 08:03
URI: http://repository-tnmgrmu.ac.in/id/eprint/328

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