Preparation and in Vitro Evaluation of Griseofulvin Microparticles Using Chitosan and Ethyl Cellulose

Anish, John (2008) Preparation and in Vitro Evaluation of Griseofulvin Microparticles Using Chitosan and Ethyl Cellulose. Masters thesis, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore.


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The present studt preparation and evaluation of microparticles containing Griseofulvlin using chitosan and ethyl cellulose were compared Estimation of the drug encapsulation efficiency of chitosan microparticles an ethyl cellulose microparticles: Different batches containing various concentrations of drug and same concentration of the polymers were prepared and estimated for the amount of drug loaded in each batch. A comparative result revealed that may be a maximum of 30 mg could be incorporated in both polymers. A comparison of the drug binding capacity of the microparticles containing two polymers showed that the drug bound to chitosan was greater than ethyl cellulose. In vitro release studies: The release pattern of the chitosan microparticles revealed a faster release (28.29%) in the first two hours (because of burst release) but ethyl cellulose showed a sustained release through the period. The the results obtained it is evident that microparticles containing Griseofulvin prepared using chitosan exhibited better yield, drug encapsulation and fast release when compared to ethyl cellulose microparticles. The fast release of chitosan microparticle may be due to the chemical cross-linking of the polymer glutaraldehyde.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Vitro Evaluation; Griseofulvin Microparticles; Chitosan; Ethyl Cellulose
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 25 Sep 2017 05:54
Last Modified: 25 Sep 2017 05:54

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