Formulation and Evaluation of Gastro Retentive Floating Tablets of Atorvastatin Calcium

Rajesh, M (2012) Formulation and Evaluation of Gastro Retentive Floating Tablets of Atorvastatin Calcium. Masters thesis, K.M. College of Pharmacy, Madurai.


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The present study oral route has been explored for the systemic delivery of drugs through different types of dosage forms. However the drug or the active moiety must be absorbed well throughout the Gastrointestinal Tract (GIT) in order to produce an optimized therapeutic effect. Absorption may be hindered, if there is a narrow absorption window for drug absorption in the GIT or if the drug is unstable in the GI fluids. Thus the real challenge is to develop an oral controlled release dosage form not only to prolong the delivery but also to prolong the retention of the dosage form in the stomach or small intestine until the entire drug is released. One of the most important approaches to control the retention of drug delivery system in GIT is by adopting Gastro Retentive Drug Delivery Systems (GRDDS). Such retention systems are important for drugs that are degraded in the intestine or drugs undergo rapid clearance in intestine like Atorvastatin calcium. Gastro Retentive Drug Delivery System of Atorvastatin calcium could be successfully formulated by direct compression technique, using different viscosity grades of Hydroxy Propyl Methyl Cellulose, Avicel PH102 was used as binder, sodium bicarbonate as gas generating agent, talc as glidant, magnesium stearate as lubricant and lactose as diluent. The optimized tablet formulation had showed 99.74% of drug release in 24 h. Therefore the optimized formulation containing HPMC K100M with Avicel PH102 sustained the drug release for a period of 24 h and remains buoyant throughout the studies. Among the different grades of HPMC, HPMC K100M showed the maximum retardation in drug release. The invitro dissolution profile of drug release from the tablets followed zero order kinetics. From the higuchi plot of dissolution profile, we found that the drug was released by diffusion mechanism and from the peppas plot we concluded that the release mechanism was found to be non Fickian release. The optimized formulation undergoes stability study at 25◦C / 60%RH, 30◦C / 65%RH, 40◦C / 75%RH. There was a slight change in physical characteristics, buoyancy study and dissolution study.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Gastro Retentive Floating; Tablets; Atorvastatin Calcium
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 25 Sep 2017 05:24
Last Modified: 25 Sep 2017 05:24

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