Development and Characterization of an Antimicrotubular Taxane Loaded MPEG‐b‐PCL Nanoparticles

Rajasekharreddy, V (2012) Development and Characterization of an Antimicrotubular Taxane Loaded MPEG‐b‐PCL Nanoparticles. Masters thesis, K.M. College of Pharmacy, Madurai.


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The present work entitled, “Development and characterisation of an Antimicrotubular Taxane loaded MPEG-b-PCL Nanoparticles” was aimed to develop a nanoparticulate drug delivery system of an anticancer drug Paclitaxel using a biodegradable amphiphilic diblock MPEG-b- PCL copolymer. The main objective of the work was to develop a controlled release dosage form of Paclitaxel nanoparticles for reducing severe side effects associated with conventional delivery system like paclitaxel injection(Taxol), because of the low solubility of paclitaxel in water, it was first dissolved in Cremophore EL (polyethoxylated castor oil) and Ethanol and then administered, use of this solvent mixture cause serious side effects like sever hypersensitivity reactions, neurotoxicity, nephrotoxicity and hypotensive reactions on iv administration. So, the inclusion of Paclitaxel in nanoparticle formulations has proved to be a good approach to eliminate effects of Cremophore EL and Ethanol. The preformulation studies were performed by using infrared spectroscopy, the obtained spectra revealed the absence of molecular interactions between the Paclitaxel, MPEG-b-PCL copolymer and PVA used in the formulation.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Characterization; Antimicrotubular; Taxane; Nanoparticles
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 25 Sep 2017 05:23
Last Modified: 25 Sep 2017 05:23

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