Rajneesh, Pandey (2009) Study on Development of Taste Masked Roxithromycin Oral Suspension by Using Cation Exchange Resin- Indion 204. Masters thesis, K.M. College of Pharmacy, Madurai.
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Abstract
The present study was focused to develop a stable oral suspension of suitable dose of Roxithromycin by masking the bitter taste to make it palatable for infants and children. Although there are various technique to mask the bitterness of a drug, literatures had proven that the ion exchange resin could mask the bitterness due to amines. Since roxithromycin produces bitterness due to amines present, the ion exchange resins was chosen a tool for the present study to mask bitter taste. The objective of the present study was to develop a stable taste masked roxithromycin oral suspension, which could be palatable for infants and children. Various batches were developed, Among that formulations (Rxso1 to Rxso6) evaluated and discussed. Formulation Rxso6 was found to be having the desirable features of stable suspension such as sedimentation volume, PH, viscosity, assay, microbial limit test. Also when subjected under accelerated condition the suspension behavior was not altered always. Hence it can be concluded that the bitter taste might be masked through the efficient drug-resin complex,(Roxithromycin-Indion 204)which was the key factor for taste masking. Further evaluation on taste masking for the formulation Rxs06 shall be studied in future with human volunteer after obtaining ethical committee permission . From all favorable result it was revealed that formulation Rxs06 can be concluded as the optimized and stable Roxithromycin oral suspension and above evaluation parameter it indicates that the RXS06 are better than the other formulations and also from microbial study it was confirmed that the final formulation(RXS06) also protected from microbial growth hence it is good suspension for administration.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Taste Masked; Roxithromycin Oral Suspension; Using Cation; |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 25 Sep 2017 05:22 |
| Last Modified: | 25 Sep 2017 05:22 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/3268 |
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