Clinicoradiological outcome in patients undergoing limb salvage operation for osteosarcoma of the distal femur and proximal tibia

Kathir Joyson, D R (2016) Clinicoradiological outcome in patients undergoing limb salvage operation for osteosarcoma of the distal femur and proximal tibia. Masters thesis, Christian Medical College, Vellore.

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Abstract

Objectives: To measure the clinico radiological out come in patients undergoing tumour excision and mega-prosthesis for osteosarcoma of the proximal tibia and distal femur in terms of survival and local recurrence. Methods: Patients who underwent tumour excision and mega-prosthesis for osteosarcoma of the proximal tibia or distal femur from January 2010 to October 2014 were included in the study. The patients records were used to finding out the local recurrence, occurrence of metastasis and to determine the survival of the patient. Phone calls were used for patients who had not come for follow up. Data regarding age, sex, value of alkaline phosphatase at diagnosis, time of metastasis, time of local recurrence, range of motion Tumor volume, tumour depth, Blackburne-Peel ratio, percentage of resection were collected from the patients records and appropriate imaging. Results: Among our patients the over all survival was 66% and the incidence of local recurrence was 20%. Most tumours belong to high grade and had large volume. Tumour volume and tumour depth were significantly associated with overall survival. Tumour volume, tumour depth and administration of radiotherapy were significantly associated with local recurrence. Tumour volume and radiotherapy were independently associated with time to local recurrence. Blackburne-Peel ratio was significantly associated decreased lag but the extent of resection of the femur or tibia did not have any functional significance. Wound infection was noted in 9 patients and 8 patients eventually underwent amputation.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Local recurrence ; Survival ; Radiotheraphy
Subjects: MEDICAL > Orthopaedics
Depositing User: Subramani R
Date Deposited: 21 Sep 2017 03:16
Last Modified: 21 Sep 2017 03:16
URI: http://repository-tnmgrmu.ac.in/id/eprint/3226

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