Correlation of inflammatory markers of periprosthetic joint infection in revision arthroplasty

Elvis, Benjamin (2016) Correlation of inflammatory markers of periprosthetic joint infection in revision arthroplasty. Masters thesis, Christian Medical College, Vellore.


Download (8MB) | Preview


OBJECTIVE: To investigate the correlation between the inflammatory markers for the diagnosis of periprosthetic joint infection in patients undergoing revision arthroplasty. HYPOTHESIS: IL-6 is an accurate, marker of periprosthetic joint infection as compared to conventional markers. METHODS: This study is a prospective, observational, cross sectional study, which included patients who were planned for revision hip or knee arthroplasty, either for loosening, implant exchange or because of periprosthetic joint infection. Preoperative inflammatory markers were sent for peripheral total white bloodcell count, the erythrocyte sedimentation rate , serum C-reactive protein levels and serum interleukin-6 . The diagnosis of periprosthetic joint infection was confirmed based on the diagnostic criteria laid by Parvizi J, et al. We analysed the sensitivity, specificity, positive predictive Value, negative predictive value and accuracy of each marker in aseptic loosening and periprosthetic joint infection and investigated the correlation RESULTS: This study demonstrated that CRP was the most accurate marker of deep infection in revision arthroplasty (Periprosthetic Joint Infection) with Sensitivity of 100%, specificity of 95%, Interleukin-6(IL-6) as a new marker was found to be less accurate than CRP, with sensitivity of 75%, specificity of 75% and Accuracy of 75%. Combination of both CRP & IL-6 can be more useful in identifying patients with deep periprostheticjoint infection, with Sensitivity of 75%, specificity of 100% and accuracy of 92.8% ,while both ESR and TLC are not useful in the diagnosis periprosthetic joint infection due to low diagnostic value.

Item Type: Thesis (Masters)
Uncontrolled Keywords: inflammatory markers ; periprosthetic joint infection ; revision arthroplasty
Subjects: MEDICAL > Orthopaedics
Depositing User: Subramani R
Date Deposited: 21 Sep 2017 03:09
Last Modified: 21 Sep 2017 03:09

Actions (login required)

View Item View Item