A Study on Prevalance of Hypothyroidism in Patients with Extra Hepatic Biliary Lithiasis

Arun Kumar, L (2016) A Study on Prevalance of Hypothyroidism in Patients with Extra Hepatic Biliary Lithiasis. Masters thesis, Madras Medical College, Chennai.


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AIM : To show the prevalence of clinical or subclinical hypothyroidism in patients with gallstones and common bile duct stones Back ground : Studies have shown an increased prevalence of previously diagnosed hypothyroidism in gallstone patient and a delayed emptying of the biliary tract in hypothyroidism, explained partly by the missing pro relaxing effect of thyroxine on the sphincter of oddi contractility. Other explanations include the known link between thyroid failure and disturbances of lipid metabolism that may consecutively lead to change of the composition of the bile and motility of biliary tract. PATIENT AND METHOD : An observational study was done in Institute of Surgery, Rajiv Gandhi Government General Hospital, Chennai between June 2014 to June 2015. For the 195 patients with diagnosed gallstone / CBD stone, full history and clinical examination was taken and laboratory blood test for T3, T4 and TSH was done. A control group of 100 patients of similar age and sex profile admitted in same time period for other illness were also evaluated for hypothyroidism. RESULTS : Out of 195 patients with gallstone 148 (76%) were females and 47 (24%) males. Thyroid disorder in form of hypothyroidism was found in 45 (23%), from this percentage 36 (24%) were females and from this 27 (18%) were subclinical and 9 (6%) were clinical hypothyroidism and males were 9 (19%) with all subclinical cases except one. This was compared with a control group of 100 patients, 80 (80%) were females and 20 (20%) males. Hypothyroidism was found in 9 (9%) patients, all female. CONCLUSION AND RECOMMENDATION : There is a significant association between hypothyroidism and gallstones / CBD stones in both genders. Gallstone and CBD stone patients, especially females should be checked for serum TSH, T3 and T4 because of high incidence of hypothyroidism among this group.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Hypothyroidism ; Patients ; Extra Hepatic Biliary Lithiasis.
Subjects: MEDICAL > General Surgery
Depositing User: Subramani R
Date Deposited: 25 Sep 2017 16:28
Last Modified: 27 Sep 2017 01:01
URI: http://repository-tnmgrmu.ac.in/id/eprint/3207

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