Bone defects managed by autograft and allograft: Retrospective and prospective analysis.

Soma Sundar, K (2016) Bone defects managed by autograft and allograft: Retrospective and prospective analysis. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION: Bone is the most commonly transplanted tissue in our body more than any other tissue or organ except blood. Unlike other tissues bone can regenerate and repair itself.. In the body autografts remains the gold standard as they are osteoconductive as well as osteoinductive and have osteogenic cells, BMP etc. Allografts are preferred over synthetic implants by value of their desirable features of natural structure, shape and strength and biological capacity of incorporation. AIM: To analyze the management of bone defects with autograft and allograft retrospectively and prospectively the outcome. MATERIALS AND METHODS Between SEP 2012 –SEP 2015, cases of autografting and cortical and cancellous allografting has been carried out at the Institute of Orthopaedics and Traumatology, after getting ethical committee approval at Madras Medical College, Chennai.Cases includes Fibrous dysplasia – 4 ,Giant cell tumour- 2,Aneurysmal bone cyst – 2, Revision hip arthroplasty- 1, Neglected acetabular fracture -3 Femur non-union -1 ,Tibial non-union -1,Fragility fracture -1. The blood of the donors were screened twice for HIV I, HIV II, HBV, HCV and VDRL once at admission and again after 3 months (window period) at review. INCLUSION&EXCLUSION: All benign tumours ,trauma cases,neglected fracture cases,non union,osteopenic fractures,age from 15-75,both males and females included are included.Donors positive for HIV antibody identifying high risk group donors,autopsy reveals occult disease,donor bone positive for bacterial contamination donor positive for HbsAG or HCV,Donor positive for syphilis are excluded. OUTCOME ANALYSIS Analysis done by Enneking scoring,Harris hip score and radiographic evaluation.Patients were followed up for an average of 13.5 months (Range 3 months – 36 months). RESULTS: Three cases of neglected acetabular fractures ,four cases of benign tumours ,one Osteopenic fracture shows excellent to good results in all aspects.One case of ABC showed recurrence,one case femur non union with allograft got infected. CONCLUSION: Autograft is superior in incorporation.Allograft can be used safely in indicated conditions.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Bone defects ; autograft ; allograft ; Retrospective and prospective analysis.
Subjects: MEDICAL > Orthopaedics
Depositing User: Subramani R
Date Deposited: 16 Sep 2017 14:24
Last Modified: 16 Sep 2017 14:24

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