An analysis of ophthalmic manifestations in AIDS patients in lieu of their CD4+T lymphocyte count.

Sivathanu, S B (2006) An analysis of ophthalmic manifestations in AIDS patients in lieu of their CD4+T lymphocyte count. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION: Human fight against emerging dreaded diseases like Tuberculosis, Syphilis and Leprosy and Malignancies is continuing for decades. Now we face still more challenging, disastrous and dangerous disease, AIDS, with its capability of destroying one’s own immune mechanism. Destroying all boundaries among the nations, races and religions, this disease spreads in a very high speed. Emerging as a global pandemic, this killer disease infected tens of millions of patients in less than three decades and orphaned more than ten million children in the same period. The HIV epidemic continues to increase at an alarming rate. The countries with large population and areas of poverty contribute the bulk of the cases. Acquired immunodeficiency syndrome (AIDS) is an infectious disease caused by a retrovirus, the Human Immunodeficiency Virus (HIV). This syndrome is characterized by a gradual decrease in circulating CD4 + T lymphocytes and subsequent development of various opportunistic infections and neoplasia. AIM OF THE STUDY: To evaluate the various ophthalmic manifestations in proven HIV seropositive patients and document findings. To find out the correlation between the CD4+ T lymphocyte count of HIV seropositive patients and the nature and severity of the ophthalmic manifestations. To study the variations in presentation of ophthalmic manifestations in different levels of immunosuppresion. This clinical study was done to evaluate the various ophthalmic manifestations in a south Indian population of HIV infected persons and to find out the correlation between the CD4+ T lymphocyte count and nature and severity of ophthalmic manifestations. A total of 60 HIV positive patients were studied. The study period extended from January 2004 to December 2005. The HIV statuses of the patients were confirmed by ELISA method in laboratories of Government Hospital for Thoracic Medicine Tambaram. The CD4+ T lymphocyte count also were done in the same laboratories. All the patients were proven cases of HIV seropositivity, and referred from GHTM with various ophthalmic complaints to the Regional Institute of Ophthalmology, Chennai. To stress the important role of the ophthalmologist in HIV patients for preventing the visual loss by early diagnosis and instituting appropriate therapy. SUMMARY: Mode of transmission in most of the patients is Trans sexual, the rest were due to IVD abuse. Most of the patients developed ophthalmic complications within 2 years of detection of HIV infection. CONCLUSION: Ophthalmic manifestations of HIV are increasingly being recognized and the role of an ophthalmologist in its diagnosis. Fundus changes are one of the most important ocular manifestations of HIV and can serve as an early indicator for the detection and assessment of progression of disease.

Item Type: Thesis (Masters)
Uncontrolled Keywords: CD4+T lymphocyte count; ophthalmic manifestations; AIDS
Subjects: MEDICAL > Ophthalmology
Depositing User: Devi S
Date Deposited: 08 Sep 2017 07:07
Last Modified: 08 Sep 2017 07:07

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