A study of clinical and functional outcome in adults with extremity soft tissue sarcoma

Madhuri, Parija (2013) A study of clinical and functional outcome in adults with extremity soft tissue sarcoma. Masters thesis, Christian Medical College, Vellore.

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Abstract

BACKGROUND: The aim was to analyse the clinical and functional outcomes in adults with soft tissue sarcoma of the extremity who underwent treatment in our institute. METHODS: The study included 60 patients who had surgery for soft tissue sarcoma of the extremity at Department of Orthopaedics, CMC Vellore between 2009 and 2011. All these patients underwent surgery with or without adjuvant radiotherapy and chemotherapy. Demographic, tumor related and treatment related data was obtained from previous records. Disease outcomes which included overall survival, local recurrence rate and distant recurrence rate and functional outcome of these patients were measured. RESULTS: With a mean follow up of 18 months, local recurrence rate was found to be 12% with average duration to detection of local recurrence being 12 months. Distant metastasis rate was 32.7% with mean duration to event being 12 months. The overall survival of patients in this study was 55% at 45 months. Functional outcome in patients undergoing limb salvage surgery was 85.6%(MSTS score) and 89%(TESS score) as compared to those undergoing amputation 40% and 60% respectively. CONCLUSION: Follow up in a developing country like ours despite the problems of long distance, language barrier and financial constraints, is achievable as we were able to get upto 83 % follow up in our study. This study shows that the group of patients with extremity soft tissue sarcoma that we encounter is different to that seen by our western counterparts. Our patients present with greater risk factors such as frequently recurrent, larger, deeper and high grade tumors. However, the local disease control rate and functional outcome obtained in our study highlight the fact that even in this population of high risk patients, with proper planning, judicious use of reconstruction techniques and adjuvant therapy limb salvage surgery for ESTS is possible to a large extent. Good local disease control has not translated into overall survival which is consistent with the present world literature and possibly due to predominance of high risk factors in our population.

Item Type: Thesis (Masters)
Uncontrolled Keywords: clinical and functional outcome ; adults ; extremity soft tissue sarcoma.
Subjects: MEDICAL > Orthopaedics
Depositing User: Subramani R
Date Deposited: 21 Sep 2017 02:48
Last Modified: 21 Sep 2017 02:54
URI: http://repository-tnmgrmu.ac.in/id/eprint/3068

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