Abirami, G (2013) Method Development and Validation of Newer Analytical Techniques. Doctoral thesis, The Tamilnadu Dr. M.G.R. Medical University, Chennai.
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Abstract
Pharmaceutical products formulated with more than one drug, typically referred to as combination products, are intended to meet previously unmet patients need by combining the therapeutic effects of two or more drugs in one product. These combination products can present daunting challenges to the analytical chemist responsible for the development and validation of analytical methods. The results drawn were confirmed by low percentage RSD values. The spectrophotometric method was found to be economical when compared to the HPLC and HPTLC method. But HPLC and HPTLC is more sensitive than UV spectrophotometric method. The low percentage RSD value in the recovery studies suggests that the excipients present in the dosage forms do not interfere in the analysis of formulation and hence all the methods are accurate. The linearity range, LOD, LOQ were less in HPLC and HPTLC method while compared to UV spectroscopic method. Hence it was suggested that the developed methods can be applied successfully for the routine quality control analysis for the simultaneous estimation of drugs in bulk and in Pharmaceutical dosage form and the obtained results can be presented elsewhere.
| Item Type: | Thesis (Doctoral) |
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| Uncontrolled Keywords: | Method, Development, Validation, Newer Analytical Techniques. |
| Subjects: | PHARMACY > Pharmaceutical Analysis |
| Depositing User: | Subramani R |
| Date Deposited: | 17 Jun 2017 03:58 |
| Last Modified: | 24 Oct 2022 10:20 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/30 |
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