A Novel Transdermal Patch Containing Lamivudine and Invitro - Invivo Characterization.

Pavan Kumar, J (2010) A Novel Transdermal Patch Containing Lamivudine and Invitro - Invivo Characterization. Masters thesis, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamilnadu, India.


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The purpose of the work was to formulate and evaluate the matrix transdermal patches of Lamivudine for the controlled delivery of the drug in the body. The patches were prepared by the solvent casting method using Span-80 as a permeation enhancer. The results of the reliminary trials indicate the drug: polymers ratio affected the characteristics of the patches. This patches were prepared in different drug: polymer ( Lamivudine:HPMC and Lamivudine:EC ) ratios of 1:2.5, 1:5, without permeation enhancers and with permeation enhancers, The drug polymer interaction was investigated by FTIR and the results indicated no incompatibility. Lamivudine patches were evaluated for various parameters like thickness, folding endurance, percentage moisture loss, percentage moisture absorption, drug content uniformity, stability studies, in vitro skin permeation, skin irritation test, statistical analysis by ANOVA, in vivo studies and invitro/invivo . The prepared transdermal patches were subjected to in vitro drug permeation study by using rat skin in Phosphate Buffer pH 7.4 for 24 hrs. The comparative statistical analytical data (ANOVA) showed ‘p’ value < 0.0001which suggest that the prepared formulations are extremely significant for transdermal delivery. The formulation (FPE2) ratio 1:5 of (Lamivudine:HPMC) patch with permeation enhancer showed best result among all formulation. This formulation (FPE2) was subjected to in-vivo studies by using rat. For in vivo studies patches were administered transdermally to rats, while a standard solution of 10μg/ml was used as a control, and collected the plasma at different time interval and analyzed by HPLC technique, and carried out the in-vitro in-vivo correlation. Thus showed a near correlation for in-vitro and in-vivo studies

Item Type: Thesis (Masters)
Uncontrolled Keywords: Novel Transdermal Patch; Containing Lamivudine; Invitro Invivo; Characterization
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 23 Jun 2017 04:47
Last Modified: 23 Jun 2017 06:07
URI: http://repository-tnmgrmu.ac.in/id/eprint/297

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