Priyanka, K (2011) Effect of Lipid on Preparation and Evaluation of Montelukast Sodium Loaded Solid Lipid Nanoparticles. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
|
Text
PRIYANKA K.pdf Download (4MB) | Preview |
Abstract
Most of the drugs introduced to clinical medicine exert their effects by interactive interference with cell and cell membrane related structure and function through concentration dependent reversible interactions at specific receptor site. Presently, conventional dosage forms (tablets, capsules, pills, injections) are primarily prescribed pharmaceutical products and are available over-the-counter. Finally, it was concluded that hot homogenization followed by ultrasonication is a feasible method. Particle sizes of SLNs revealed that the SLN prepared from higher melting point lipid showed larger particle size and with increased carbon chain length of the fatty acids. FTIR and DSC studies suggested that there is no interaction between drug and lipids. Studies showed that, increase in lipid concentration increased particle size, EE, and maintained the sustained release of drug. Among all, Compritol ATO 888 is chosen as the best lipid for formulating SLN because it had higher EE and sustained drug release profile than GMS and stearic acid. It was concluded that the SLN provide sustained release and are preferred to overcome oral bioavailability problems and suggests that montelukast sodium can formulate as SLN system.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Effect of Lipid ; Preparation ; Evaluation ; Montelukast ; Sodium ; Solid Lipid ; Nanoparticles. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 23 Jun 2017 04:23 |
| Last Modified: | 22 Dec 2018 09:30 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/296 |
Actions (login required)
 |
View Item |
