Nidhin, C (2012) Design and Characterization of Floating Tablets of Ranolazine. Masters thesis, J K K Munirajah Medical Research Foundation College of Pharmacy, Komarapalayam.
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Abstract
The proposed formulation is developed by considering the drawbacks associated with the conventional controlled drug delivery system. The formulation may remained in the stomach and / or upper part of GIT for prolonged period of time thereby giving sufficient time for drug candidate to achieve maximum bioavailability and reduce unwanted side effects by minimizing or avoiding drug release at unfavorable site.From the above study it can be concluded that promising controlled release by gastro retentive floating tablets of Ranolazine was developed using a combination of HPMC K15M and Chitosan. The floating tablet of Ranolazine was capable of maintaining plasma drug concentration through 12 hrs. The release rate of the drug from the floating tablets was significantly influenced by the proportion as well as viscosity of the polymer used. The formulation RF8 was selected as an optimized formulation because it gave the best result in terms of the required in-vitro buoyancy study, good floating integrity and drug release in sustained release manner. The release profile of the optimized formula, fitted best to Korsmeyer- Peppas model with R2 value of 0.975.As the n value for the Korsmeyer-Peppas model was found to be less than 0.89, it follows case-2 transport.In-vivo radiographic studies revealed that the tablets remain in the stomach for 300±10 mins which indicates the increase in the gastric residence time. Short-term stability studies indicated no appreciable changes in the drug content and In-vitro drug release rates of formulation RF8. The aim of the present dissertation work is to sustain the release of drug due to floating in stomach at acidic pH 1.2 up to 12 hrs.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Ranolazine; Korsmeyer Peppas; In-vivo radiographic studies |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 24 Aug 2017 04:27 |
| Last Modified: | 24 Aug 2017 04:27 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2817 |
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