Jayaselvi, S (2012) Formulation and Evaluation of Floating Tablet formulation and Evaluation of Floating Tablets of Ciprofloxacin HCL. Masters thesis, J K K Munirajah Medical Research Foundation College of Pharmacy, Komarapalayam.
|
Text
26106505 Jayaselvi S.pdf Download (4MB) | Preview |
Abstract
The present study is to formulation and evaluation of floating tablets of Ciprofloxacin Hcl using HPMC by direct compression techniques. A rationale for developing Ciprofloxacin Hcl as a gastroretentive dosage form, which is retained in the stomach for prolonged period of time and produces a constant input of drug to the absorption site. This improves bioavailability of the drug, reduces frequency of dosing, thus minimizing side effects.Ciprofloxacin is a broad-spectrum antibiotic active against both Gram-positive and Gram-negative bacteria. It is absorbed completely (91 – 95%) after oral administration and having a biological half-life of 3 to 5 hrs. The drug should be administered twice a day. The objective of the present study is to formulate the Ciprofloxacin Hcl floating tablets using HPMC (K100M, K4M and E50) in different ratio with sodium bicarbonate and lubricants by direct compression techniques. Hydrodynamically balanced tablets of Ciprofloxacin Hcl can be formulated with an approach to increase gastric residence and thereby improve drug bioavailability. An attempt to develop floating tablets of Ciprofloxacin Hcl, using sodium bicarbonate as gas generating agents and HPMC as hydrophilic polymer by direct compression technique was achieved.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Ciprofloxacin HCL; Hydrophilic polymer; Gastroretentive dosag |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 23 Aug 2017 11:53 |
| Last Modified: | 23 Aug 2017 11:53 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2815 |
Actions (login required)
 |
View Item |
