Analysis of thyroid-stimulating hormone receptor antibodies in various thyroid diseases.

Zahir Hussain, S (2011) Analysis of thyroid-stimulating hormone receptor antibodies in various thyroid diseases. Masters thesis, Madras Medical College, Chennai.


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Detection of thyroid antibodies can be helpful in establishing the diagnosis of autoimmune thyroid disease. All autoimmune thyroid diseases share common immunological markers.1 Antibodies against TSHR represent only one family of thyroid antibodies. Others include TPO antibodies and antithyroglobulin antibodies. Objective: To study the Thyroid Stimulating Receptor Antibodies (TSHRAb) level in various thyroid Disease by analyzing the TSH receptor antibodies level and comparing it with other thyroid antibodies and to analyze the importance of its estimation in various Thyroid Diseases with Hyperthyroidism or Hypothyroidism. Design: 70 patients of various thyroid disease admitted in the period between 2008- 2010 were included in the study. After classifying the patients on the basis of anatomical, physiological and pathological diagnosis, serum levels of thyroidstimulating hormone receptor antibodies (TSHRAbs) were assayed along with antithyroperoxidase antibodies and antithyroglobulin antibodies. Clinical features like eye signs, tremors and thyromegaly were assessed. Results were tabulated and analyzed. Results: Out of the 70 patients included in this study, 29 patients were found to have elevated TSHRAb levels. Elevated TSHRAb levels correlated with serum alkaline phosphatase levels, hyperthyroidism, Graves’ disease and ophthalmopathy. Out of 60 patients with multinodular goiter, 25 had elevated levels of TSHRAbs, which indicated the association of autoimmune thyroid disease (Graves’ disease) with multinodular goiter. Conclusion: The levels of TSHRAb grossly parallel the degree of hyperthyroidism, the grade of thyromegaly and presence of ophthalmopathy. Elevated levels of Serum Alkaline phosphatase along with TSHRAb in hyperthyroidism may be taken as a marker for severity of Graves’ disease.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Thyroid-stimulating; hormone receptor antibodies; thyroid diseases
Subjects: MEDICAL > Endocrine Surgery
Depositing User: Kambaraman B
Date Deposited: 23 Jun 2017 06:23
Last Modified: 23 Jun 2017 06:56

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