Toxicity study on Veera Chenduram

Prem Kumar, T (2007) Toxicity study on Veera Chenduram. Masters thesis, National Institute of Siddha, Chennai.

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Abstract

INTRODUCTION : The efficacy of many siddha preparations have been established but their safety are not the siddha physicians should embrace ourselves the siddha drugs are indeed safe and we should do this by using well established, modern and scientific methods. Veera chenduram a widely used siddha medicine, contains perchloride of mercury found in mountains naturally. This is used for the treatment of several ailments. This toxicity study of veera chenduram just a small step in the right direction of establishing the safety of siddha drugs. AIM & OBJECTIVES : Veeram is one of the pancha soodham in Siddha system. It is used for many diseases in Siddha system of medicine. AIM The aim of the dissertation is toxicity studies of Veera Chenduram. OBJECTIVES The toxicity of Veera chenduram has been evaluated in the following aspects: 1. Collection and Identification of the test material, 2. Purification of the raw drug Veeram, 3. Preparation of the Veera chenduram, 4. XRD study of the Veeram (impure), purified Veeram and Veera chenduram, 5.Toxicological studies of the veera chenduram. MATERIALS AND METHODS : Procurement of the Veeram: The drug was collected from the local market in Chennai. Identification of Veeram: The Veeram was identified as mercuric Chloride by the base of its physical properties in chemical laboratory. Purification of the Veeram: The purification method of Veeram was selected in accordance with the reference made in the Gunapadam Thathu Jeeva Vaguppu. 1 palam of camper was dissolved in tender coconut and kept in a mud pot. 1 palam was suspended over the contents of pot and heated for ½ hour. Preparation of Veera Chenduram: 1 palam of veeram and venkaram was taken in a mud pot. Fried it up to chenduram consistency. RESULTS : The sample of Veeram is matched with standard graph mercuric chloride. The sample of venkaram is matched with standard graph of sodium biborate. The sample of purified venkaram is matched with standard graph of Tincalconite. CONCLUSION : In conclusion, these findings suggest that the Veera Chenduram is practically toxic or lethal after an acute exposure at the dose level of 1g/kg. The Veera Chenduram affects almost all the vital organs at the maximum dose range of 200mg/kg. The normal human dose is very minimal to compare the study group doses. If given the test drug as per literature do not produce toxicity. Hence, to avoid the major adverse reactions the duration of treatment is minimized. Because of an ideal man of 70 k.g. body weight requires 4mg of the drug two times daily. But rats body weight are approximately 100 – 120gms. We have given 50mg /kg, 100mg/kg, 200mg/kg daily. These doses are more than human dose. So we can come to conclusion that the drug was in normal dose it might not produce any pathological changes. The aim of giving such a high dose was to find out the type of toxicity if the drug was given in abnormal high dose. This toxicity due to overdose could occur in a patient, if proper dose is not prescribed by the physician or followed by the patient.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Veera Chenduram ; Toxicity study.
Subjects: AYUSH > Nanju Noolum Maruthuva Neethi Noolum
Depositing User: Subramani R
Date Deposited: 22 Aug 2017 04:35
Last Modified: 29 Dec 2018 17:22
URI: http://repository-tnmgrmu.ac.in/id/eprint/2785

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