Ponmariammal, P (2007) Acute and Subacute Toxicity study on Venkara Parpam. Masters thesis, National Institute of Siddha, Chennai.
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Abstract
INTRODUCTION : Venkara Parpam comprising mainly Venkaram & egg albumin as major ingredients which are good for their diuretic and Nutritive property is used among many of the traditional practioners now and then. It is useful for moothira kiricharam (urinary tract infection) & neer adaippu. AIM AND OBJECTIVES : The main aim of the dissertation work is to study the toxic effects of short term administration of “Venkara Parpam”. The prime object of this study is to find out the acute and sub acute toxicity of Venkara Parpam by using animal models (Wistar albino rats). The main aim at the back of author’s mind is to brought out the drug into the scientific light so that the clinicians will find more confidence over the drug. The study will be complete and made useful by corroborating the comprehensive knowledge of siddha system with modern concept about lethal dose, therapeutic dose, signs and symptoms, and bio-chemical mechanism. The following specific objectives have been drawn to achieve the above aim. • Collecting literary evidences in detail about the Venkara Parpam • Collecting the Physio Chemical, Gunapadam and Toxicological aspects of the constituents of Venkara Parpam. • To know the lethal dose, therapeutic dose and usage of Venkara Parpam in general. • To find out the chemical combination of the drug through chemical analysis. • To find out and define the toxicity of the drug by Acute and sub acute toxicity study. • To support the study of toxicity using Histopathological investigations. • To discuss, whether this drug has got any side effects in short term administration to patient. MATERIALS AND METHODS : The drug was collected from local market in Chennai. The drug was identified as Venkaram by Gunapadam Department, National Institute of Siddha, Chennai. The drug was powdered well and fried in a mud vessel until the water content of it evaporates. Preparation of Venkara Parpam : Required incredients: Purified Venkaram – 1 palam (35 gms), Egg albumin – from 2 eggs. Method of preparation: Purified venkaram was powdered in the stone mortor. Then the powder was grinded with egg albumin for four days continuously. Until it becomes a wax consistency finally made disc, the disc was allowed to dry and put a putam with 25 cow dung cakes. Next day after cooling the above disc was grinded and measured. Dose: 2-3 grains (130-195mg) Vehicle: Butter, ghee, tender coconut water or water. Indications: Vellai, Moothira kiricharam (Urinary tract infection), Neer adaippu etc. CONCLUSION : Venkaraparpam didn’t produce death even up to the dose of 4 gms as random (in albinorats). The animals did not show any changes in general behaviour or other physiological activities. There were no significant differences between the control and treated groups in the body and organ weights of male and female rats. No pathological alterations were grossly detected. Therefore, we come to a conclusion that even upto 4 gms of Venkaraparpam never produce death in man. Also the doses taken in sub acute study did not produce any mortality in animals. But they produced some significant histopathological changes in the kidney. Even, this may be due to continuous administration of this drug for a long period at relatively higher doses when compared to man. Because an ideal man of 70 k.g. body weight requires 200 mg of the drug 3 times daily. But rats body weight is approximately 100 – 120 gm. But we have given 200 mg per kg, 400 mg per kg and 600 mg per kg daily. These doses are more than human dose. So, we can come to a conclusion that if the drug was in normal dose it might not produce any pathological changes. The aim of giving such a high dose was to find out the type of toxicity if the drug is given in abnormal high doses. This toxicity due to overdose could occur in a patient, if proper dose is not prescribed by the physician or followed by the patient.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Venkara Parpam ; Acute ; Subacute ; Toxicity study. |
| Subjects: | AYUSH > Nanju Noolum Maruthuva Neethi Noolum |
| Depositing User: | Subramani R |
| Date Deposited: | 22 Aug 2017 04:33 |
| Last Modified: | 29 Dec 2018 17:21 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2784 |
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