Vijayalakshmi, N (2008) A Toxicity study on Nabi Mathirai. Masters thesis, Government Siddha Medical College, Palayamkottai.
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Abstract
INTRODUCTION : Nabi is one of the widely used siddha medicine in general practice and also nabi is the one of the cardiac poison. After purification it is used as suram (fever) in siddha medicine. Nabi mathirai, is high potency drug comprising mainly, 1. Nabi, 2. Vengaram, 3. Milagu. As major ingredients which are good for their anti pyretic properties is being used by many of the traditional practioners, nowadays it is also used to cure all kinds of Sura noigal (Fever). On the other hand the ingredients of Nabi mathirai are basically heavy toxic substances. Administration of these substance, without proper purification, (suthi). In human body may lead to severe complications even death also. AIM AND OBJECTIVES : the main aim of the dissertation work is to study the toxic effects of Nabi mathirai short term and long term administrations. The prime object of this study is to find out the acute and chronic toxicity study. ♠ Acute toxicity study, ♠ Chronic toxicity study, ♠ Hematological investigations, ♠ Histopathological study of the organs such as kidney, heart and liver in albino rats, ♠ Bio chemical analysis, ♠ And Statistical Analysis of the medicine Nabi mathirai. MATERIALS AND METHODS Selection of Drug “NABI MATHIRAI mentioned in “Skitcha Rathna Deepam ennum Vaithya Sinthamani II part” was chosen and prepared as per the procedure mentioned below the drugs were collected from the local market, through proper identification. The ingredients of Nabi Mathirai are NABI, Venkaram (Borax), Vellai milagu (white pepper), Inji (Zingher officinale) – (ginger juice). Purification (Suddhi) of Raw Drugs: • NABI : The roots are soaked in cow’s urine for 3 days and then dried. • Venkaram (Borax) : The borax is fried to be free from moisture. • Vellai Milagu : Vellai milagu is fried in a mud pan it make it moist free. RESULT : The mean value of body weight and haematological indices for the three groups of rats, each group containing 5 animals with two different dosage levels were observed and the results were tabulated in Tables 7, 8 and Table 9, for the control, 40mg/body weight of the animal and 80mg/body weight of the animal, dose groups respectively. Histopathological studies reveal that the drug Nabi mathirai on long term administration shows pathological changes in the kidney and heart. So, the drug may produce less toxic effects on long term use. CONCLUSION : Nabi mathirai did not produce death even up to the dose of 640mg as random. Heamatological report also has no significant changes. In Histopathological studies of the kidney and heart shows mild changes. Therefore, we come to conclusion that even upto 640mg of Nabi mathirai never produce death in man. Also the doses taken in Acute and Chronic study did not produce any mortality in animals. But in chronic toxicity study produced mild histopathological changes in the kidney and heart. Even this may be due to continuous administration of this drug for a long period at relatively higher doses when compared to man. Because an ideal man of 70kg body weight requires 100mg of the drug 2 times daily. So, a rat of 100gm body weight requires only 0.43mg of the drug one time daily. But we have given above the normal dose. These are 4 to 8 times more than human dose. So, we can come to conclusion that if the drug was normal dose it might not produce any pathological changes.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Nabi Mathirai. |
| Subjects: | AYUSH > Nanju Noolum Maruthuva Neethi Noolum |
| Depositing User: | Subramani R |
| Date Deposited: | 22 Aug 2017 04:29 |
| Last Modified: | 29 Dec 2018 17:25 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2783 |
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