Raja, K (2008) A Study on Kovai Kizhangu Choornam (Coccinia Grandis Linn) for Neerizhivu and A Study on Shanmuga Mezhugu for Azhal Keel Vayu. Masters thesis, National Institute of Siddha, Chennai.
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Abstract
Part I - A STUDY ON KOVAI KIZHANGU CHOORNAM (Coccinia grandis Linn) for NEERIZHIVU - INTRODUCTION : The condition neerizhivu due to vitiation of kapa humour and is followed by pitham and vatha derangement. Consequently the seven udal thathus also gets affected and the patient becomes terminally ill. Since early times, herbs have been used for healing purposes and maintaining good health. In treating the disease Neerizhivu large number of herbs, mineral etc have been successfully tested in laboratory. The drug Kovai Kizhangu Choornam indicated for Neerizhivu in Siddha literatures. In this dissertation the author has to evaluate the Antidiabetic activity of Kovai Kizhangu Choornam. AIM AND OBJECTIVE : AIM: The aim of the dissertation is to evaluate the efficacy of Kovai Kizhangu Choornam for Neerizhivu (Diabetes mellitus). OBJECTIVE: Neerizhivu is a chronic metabolic disorder characterized by hyperglycaemia, glycosuria, pruritis vulva, balanitis, weight loss and nonspecific malaise. It is a disease causing serious and long term complications. There is no permanent remedy for neerizhivu in conventional medicine. The people are searching for an uncomplicated and managing therapy for neerizhivu. Since, no analysis has been made so far in Kovai Kizhangu Choornam for the disease Neerizhivu. So, the author has selected the drug to prove its efficacy on the same. The efficacy of Kovai Kizhangu Choornam has been evaluated in following aspects: • Collection of literary evidences in Siddha and botanical aspects. • Biochemical analysis, • Pharmacological study, • Clinical assessment. MATERIALS AND METHODS : To evaluate the efficacy of “Kovai Kizhangu Choornam” for “Neerizhivu” (Diabetes Mellitus) has been selected as per siddha literature, Gunapadam Mooligai vaguppu. Collection of the drug: Fresh tubers of kovai were collected from Sholinghur. Its botanical identity was authenticated by botany professor of National Institute of Siddha. Preparation of the test drug: The collected tubers were cleaned with water and dried in shade. Then it is made into fine powder. It was filtered by a white cloth (Vasthirakayam). Intended therapeutic use: Kovai Kizhangu Choornam in the dose of 1 g t.i.d with luke warm water is given for Neerizhivu before meals. CONCLUSION : The drug Kovai Kizhangu Choornam has been selected for the study to establish its efficacy in the management of Neerizhivu as an important aspect of this dissertation work. The review of siddha literature about the drug describes the antidiabetic activity of the drug. Information about the drug from various literatures was also referred. Bio-chemical analysis of the drug reveals the presence of minerals namely Magnesium, Zinc, Copper, Selenium and Calcium. Pharmacological studies showed that the drug has got significant anti diabetic property at the dose of 400 mg/kg and no significant adverse effects. From the clinical assessment, it is inferred that the drug has marked response in Neerizhivu without any significant adverse effects. This is concluded that the drug Kovai Kizhangu Choornam has got significant anti diabetic activity, effective in Neerizhivu without causing any adverse effects. Part II - A STUDY ON SHANMUGA MEZHUGU for Azhal Keel Vayu - INTRODUCTION : The drug Shanmuga Mezhugu has been mentioned in siddha literatures to be effective in the treatment of Azhal Keel Vayu. Shanmuga Mezhugu contains Veeram, Pooram and Lingam as its main ingredients and these three has the property of neutralizing the Vatha humour and subsequently the Pitha humour. So, in this dissertation the author has to evaluate the anti-inflammatory, analgesic and antipyretic of Shanmuga Mezhugu. AIM AND OBJECTIVE ; Aim: The aim of the dissertation is to evaluate the efficacy of Shanmuga Mezhugu for Azhal Keel Vayu. Objective: Azhal Keel Vayu is the most common joint disease of human and leading cause of disability in elderly and it has become a challenging problem to find out a permanent solution for this disease. Even though many anti-inflammatory, analgesic and anti-pyretic drugs are there in conventional medicine, they are only time being and have side effects. This urged the author to find a safe and easily available drug, which is not having any adverse effects. Since, no analysis has been made so far in Shanmuga Mezhugu for the disease Azhal Keel Vayu. So, the author has selected the drug to prove its efficacy on the same. The efficacy of Shanmuga Mezhugu has been evaluated in following aspects: • Collection of literary evidences in Siddha aspect. • Gunapadam aspect, • Botanical aspect, • Biochemical analysis, • Pharmacological analysis, • Clinical assessment. MATERIALS AND METHODS Preparation of the drug: To evaluate the efficacy of “Shanmuga Mezhugu” for “Azhal Keel Vayu” (Osteo Arthritis) has been selected as per siddha literature, Anupoga Vaithya Navaneetham by Abdullah sayabu. The Ingredients of Shanmuga Mezhugu are, Veeram, Pooram, Lingam, Chukku, Elarisi, Kirambu, Thaen. Collection of Drugs: The raw drugs like veeram, pooram, lingam, chukku, elarisi, kirambu and thaen were collected from the indigenous drug shop, Chennai. METHOD OF PREPARATION: INGREDIENTS: Veeram - 105g, Pooram - 105g, Lingam - 105g, Chukku - 315g, Elarisi - 315g, Kirambu - 315g, Thaen - 1260g. Purification of the drugs: Purification of Lingam: Equal quantities of lemon juice, cow’s milk and Acalypha juice were mixed thoroughly. Lingam was kept in a mud vessel and heated. The above prepared juice was poured into the Lingam little by little until the entire juice finished off. Purification of Veeram: Camphor was mixed with tendor coconut and put in a mud vessel. Veeram enclosed in a thin cloth was made hanging inside the vessel above the liquid level without touching it. Then the vessel heated for half an hour. Purification of Pooram: Equal parts of betle leaves (Kammaru vetrilai) and pepper were made into a paste by grinding with some water. Then the paste was mixed with more water and poured into a mud vessel. Pooram enclosed in a thin cloth was made hanging inside the vessel and was kept immersed in the liquid level fully. Then the vessel was heated gently until the liquid inside the vessel reduced into one fourth of its original quantity. Then the Pooram taken out and washed in water, then kept in sun for drying. Purification of Chukku: To purify Chukku the outer skin of it was peeled off by using a knife. CONCLUSION : The drug Shanmuga mezhugu has been selected for the study to establish its efficacy in the management of Azhal Keel Vayu as an important aspect of this dissertation work. The review of siddha literature about the drug describes the Anti-inflammatory, Antipyretic and analgesic activity of the drug. Information about the drug from various literatures was also referred. Bio-chemical analysis of the drug reveals the presence of minerals namely calcium, copper, zinc, iron, manganese, mercury, magnesium and reducing sugar. The acute toxicity study shows that the drug is safe and no significant adverse effects up to dose level of 4000mg/kg. Pharmacological studies showed that the drug has got significant analgesic, antiinflammatory and antipyretic properties at the dose of 400 mg/kg and no significant adverse effects. From the clinical assessment, it is inferred that the drug has marked response in Azhal Keel Vayu without any significant adverse effects. This is concluded that the drug Shanmuga mezhugu has got significant Analgesic, anti-inflammatory and antipyretic activity, effective in Azhal Keel Vayu without causing any adverse effects.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Kovai Kizhangu Choornam ; Coccinia Grandis Linn ; Neerizhivu ; Shanmuga Mezhugu ; Azhal Keel Vayu. |
| Subjects: | AYUSH > Gunapadam |
| Depositing User: | Subramani R |
| Date Deposited: | 22 Aug 2017 02:05 |
| Last Modified: | 29 Dec 2018 15:26 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2769 |
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