Mohamed Halith, S (2012) Novel Approaches for Niosomal Drug Delivery in Cancer Chemotherapy. Doctoral thesis, (Synopsis) The Tamilnadu Dr. M.G.R. Medical University, Chennai.
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Abstract
INTRODUCTION : Today the challenge to drug delivery scientists is to work and investigate to deliver the drug using promising drug carriers including biodegradable polymers. The systems that are capable of releasing the therapeutic agents by well defined kinetics are available at present. But in many cases these don’t yet represent the ultimate therapy to needs of recipient. Hence attention should also be focused to fabricate controlled, modulated drug delivery system that are capable of receiving the physiological feedback information and adjusting the drug output and system that are capable of precisely targeting the specific tissue or cells. Novel drug delivery provides either sustained drug action at a predetermined rate or by maintaining a relatively constant, effective drug level in the body with concomitant minimization of undesirable side effects. Niosomes are non ionic surfactant vesicles which can entrap both hydrophilic and lipophilic drugs, either in aqueous layer or in vesicular membrane made of lipid materials. Niosomes are either unilamellar or multilamellar vesicles that have a better stability than liposomes. AIM : In order to fulfill the need of a long term treatment with anti cancer drugs in conventional dosage forms, where most of them suffer from the drawbacks of frequent administration and inadequate plasma concentration, it is desirable to have sustained-release drug delivery systems to improve the overall therapeutic benefit and to achieve an ideal therapy regime. By sustained delivery, it is possible to achieve effective plasma concentration without significant fluctuation, to avoid subtherapeutic and toxic plasma concentrations, to facilitate release of the medication in a controlled manner to obtain a continuous delivery, to achieve an effective therapy with low dosage of the drug, to reduce the frequency of medication and thus to improve patient adherence. Materials and Methods : Drugs: Methotrexate, Tamoxifen, Cisplatin. Surfactants used: Span 20, Span 40, Span 60, Span 80, Tween 20, Tween 40, Tween 60, Tween 80 and Brij 35. Others: Cholesterol and Dicetyl phosphate. All the Solvents and Chemicals used were of AR or GR grade. Solvents : Diethyl ether, Acetone, Chloroform, Methanol. CONCLUSION : In the present study anti cancer drugs viz, Methotrexate, Tamoxifen and Cisplatin were selected to formulate into niosomes to achieve controlled drug delivery to increase cytotoxic activity. To formulate niosomes to achieve effective management of cancer. The preformulation studies were performed by using FTIR. The spectra of crude drugs and their physical mixtures were examined. The study revealed the absence of significant interactions between drug and additives. Niosomes of Methotrexate, Tamoxifen and Cisplatin were prepared successfully by using thin film hydration technique. Relationships between surfactant type and characterization parameters of niosomes were established. In the present study, the findings revealed that the process variables critically affect the formulation of niosomes with regards to drug entrapment and need to be carefully controlled. The process optimized parameters like speed of rotation 150rpm and 2hour hydration time. The results of this study showed that cholesterol content and the type of surfactant altered the entrapment efficiency and drug release. Entrapment efficiency and in vitro studies showed that optimized formulations might be more beneficial for drug delivery among other formulations. The results presented in this study indicate that the long circulation of niosomes offer a potential application to improve the pharmacokinetic parameters. Anti-cancer studies by using cell lines namely DAC optimized formulation of Methotrexate, Tamoxifen and Cisplatin niosomes posses significant anti-cancer activity. This is due to prolonging the circulation of entrapped drug and altering its organ distribution and metabolic stability of Methotrexate, Tamoxifen and Cisplatin, niosomes. The targeting effect may increase the anticancer activity of the drug and potentially improve its therapeutic benefits. Invivo studies show encouraging results.
| Item Type: | Thesis (Doctoral) |
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| Uncontrolled Keywords: | synopsis, Novel approaches, niosomal drug delivery, cancer chemotherapy. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Subramani R |
| Date Deposited: | 20 Aug 2017 13:11 |
| Last Modified: | 24 Oct 2022 14:12 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2747 |
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