Histomorphological Characterization of Adult Renal Neoplasms

Suresh, M (2007) Histomorphological Characterization of Adult Renal Neoplasms. Masters thesis, Madras Medical College, Chennai.


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Adult renal tumors comprise of neoplasms originating from renal tubular epithelium, urothelium of pelvis, mesenchymal tumors and mixed type of tumors. Among these, renal cell carcinomas (RCC) form the largest group. Over the recent years, there has been approximately 3% annual increase world wide1 in the age adjusted incidence of renal cell carcinoma. RCC is actually a group of cancers, each with a common cellular origin, distinct genetic abnormalities and unique morphological features. A number of risk factors – cigarette smoking elevated Body Mass Index, hypertension, having a first degree relative with kidney cancer, End stage Renal Disease2 have been identified RCC is known to occur sporadically as well as part of inherited cancer syndromes like Von Hippel Lindau Syndrome, Hereditary papillary RCC, Birt Hogg Dube syndrome, Hereditary leiomyoma RCC3. The clinical presentation and management of RCC are changing very rapidly, driven by advances in medical imaging, genetics, molecular pathology, surgery, immunotherapy and targeted therapy. The clinical outcomes of the various histological subtypes are different and accurate histological classification needs attention to gross features, architectural and cytological characteristics with support from histochemical, immunohistological and cytogenetic studies. Transitional cell carcinoma (TCC) of renal pelvis contributes to a significant proportion of adult renal neoplasms. They are essentially similar to TCC arising in the ureter / urinary bladder. Oncocyloma and Papillary adenoma are benign renal epithelial neoplasms that have to be differentiated from renal cell carcinoma and can be cured by nephrectomy alone. Angiomyolipoma is the most common mesenchymal tumor of kidney and was previously considered to be a hamartoma. It has recently been proposed that the periepitheloid cell4 is the cell of origin. Although the diagnosis of angiomyolipoma is usually straight forward, some cases may show unusual morphological features that may sometimes lead to erroneous diagnosis of malignancy.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Histomorphological Characterization ; Adult Renal Neoplasms
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 22 Jun 2017 11:33
Last Modified: 22 Jun 2017 11:33
URI: http://repository-tnmgrmu.ac.in/id/eprint/273

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