A Clinico Pathological study of Meningiomas.

Radha, A (2007) A Clinico Pathological study of Meningiomas. Masters thesis, Madras Medical College, Chennai.


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“The pathological curiosity of one day becomes in its proper time a common place condition at a later time”. Sir Harvey Cushing Meningiomas were once considered a complex and diverse group of neoplasms in view of their varied histological patterns. Over the years these morphologically different tumours have been studied in detail and the mysteries of their origins unraveled. The term “meningioma” was coined by Sir Harvey Cushing, the most revered neurosurgeon of the 20th century. But as early as 1614 Felix Plater removed a brain tumor at autopsy which he described accurately. The neoplasm was in all probability a meningioma. The first brain tumour reported from the United States also happens to be a meningioma. In 1835, Professor Peccholi, Professor of Surgery and Operating Medicine from the University of Siena operated on a dural based tumour at the occiput which he described as a “fungus of the dura mater”. Over a period of 16 years he operated upon and studied the morphology of several such tumours and published a comprehensive review of his work in 1847. Francesco Durante of Sicily, Italy, was the first surgeon to successfully resect a cranial base meningioma. But the most celebrated work on meningiomas is by Sir Harvey Cushing co – written by Louise Eisenhardt in 1938 titled “Meningiomas : Their classification, regional behaviour, life history and surgical end results”. This works gives incredible details and morphological descripotions of meningiomas. Various authours over the years have attempted to classify meningiomas. It was understood that most of these tumours followed a benign course and that morbidity and mortality relating to them stem from unusual locations and limitations to surgical resectablity. Cushing5 identified 20 subtypes that included non meningothelial mesenchymal tumours too. Further refinement down the year divided meningiomas in to benign, atypical and malignant variants. The 1993 WHO classification28 recognizes two broad categories of meningeal neoplasms : 1. Meningiomas arising from meningothelial (arachnoidal cap) cells 2. Tumours arising from mesenchymal non meningothelial cells which are classified as soft tissue tumours. Kustanikul and Brown42 attributed the histological diversity of meningiomas to the pluripotential nature of mesenchymal stem cells arising from the neural crest.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Meningiomas; Clinico Pathological study
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 22 Jun 2017 11:37
Last Modified: 22 Jun 2017 11:37
URI: http://repository-tnmgrmu.ac.in/id/eprint/270

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