Rajanish Kumar Reddi, Dodda (2012) Formulation and Evaluation of Diclofenac Solid Dispersion Incorporated Topical Gel. Masters thesis, Nandha College of Pharmacy, Erode.
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Abstract
The diclofenac sodium shows poor aqueous solubility and oral administration causes irritation of gastro intestinal tract, lack of bioavailability. The aim was to investigate the potential of diclofenac loaded solid dispersion based gel for topical delivery in order to improve the solubility, thereby increasing the bioavailability of drug. This alternate topical route eliminates oral side effects, increases patient compliance, avoids high first pass metabolism and maintains the plasma drug level for a longer period of time. Solid dispersion incorporated diclofenac gel are thermodynamically stable. The solid dispersions are prepared by kneading method (β cyclodextrin) and solvent evaporation technique (PVP), followed by being incorporated into Carbopol 934 and HPMC based gel matrix to form solid dispersion incorporated diclofenac solid dispersion incorporated tropical gel. Among the solid dispersion, formulation which showed highest release was selected to incorporate with Carbopol 934 and HPMC base to form gel. On the basis of swelling index invitro release studies, spreadability, viscosity, homogenization, saturation solubility study, we selected FG1 formulation which contained the combination of Diclofenac sodium, βcyclodextrin solid dispersion incorporated, carbopol 934 Gel for the use of invitro and in vivo studies. The optimized gel (FG1) was taken for their invitro skin permeation study, in vivo anti-inflammatory, effects and skin irritation study. The invitro and in vivo study for optimized diclofenac solid dispersion incorporated gel FG1 were compared with Marketed gel, revealed a significant increase in skin permeation profile and anti-inflammatory effects for optimized gel. The percent inhibition value of optimized gel after 12 hours of administration was found to be 5.22% as compared with 5.41% for Marketed gel. From invitro and in vivo data it can be concluded that optimized carbopol gel containing diclofenac solid dispersin have great potential for topical delivery.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Diclofenac Solid; Bioavailability; Thermodynamically stable |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 18 Aug 2017 10:01 |
| Last Modified: | 18 Aug 2017 10:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2688 |
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