Aneef Mohammed, Yakub (2012) Solubility Enhancement of Co-Crystal Based Solid Dosage Form. Masters thesis, J K K Nattraja College of Pharmacy, Komarapalayam.
|
Text
26103001 Aneef Mohammed Yakub.pdf Download (4MB) | Preview |
Abstract
The present study is to enhance the solubility of co-crystal based solid dosage from, from physical properties perspective, a key advantage of co-crystals as a solid form of an API is the possibility of achieving the high dissolution rate comparable to that of the amorphous form, while maintain the long term chemical and physical stability that crystalline forms provide. A major problem in the use of bioactive herbal ingredient curcumin as a therapeutic agent is its low solubility and bioavailability, Basic goal in the development of co-crystal is to increase the solubility, stability and dissolution rate pure drug curcumin. In particular substantial advancement method of crystal engineering supramolecular technique alter the physicochemical properties of curcumin which can relatively undergoes for formulation. Despite lack of precedence in marketed products and concerns about the safety and toxicity of co-crystal formation and methods of preparation . Although, some recent developments in crystal and particle engineering have been included nowadays, consideration of established approaches such as the use of high-energy amorphous and metastable crystalline form is still widespread, In particular substantial advancement methods of crystal engineering , supramolecular technique alters the physicochemical properties of Curcumin which can relatively undergoes for formulation. The stability of curcumin at physiological pH may be ascribed to the β- diketone linker in the seven carbon chain of curcumin. A crystal engineering approach was utilized to prepare1:1 cocrystals of curcumin with resorcinol by liquid-assisted grinding. We reasoned that the reactivity of the keto-engol group could be modified through hydrogen bonding with phenolic compounds in co-crystals, which in turn might provide more soluble and stable curcumin solid-state forms. A solid form creeen of curcumin with phenolic conformers were characterized by FT-IR X-ray powder diffraction, and thermal techniques. The present results on more soluble cocrystals of curcumin could provide faster dissolving solid forms of curcumin that are relatively stable for drug development.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | curcumin; Bioactive herbal; Bioavailability |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 18 Aug 2017 09:43 |
| Last Modified: | 18 Aug 2017 09:43 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2686 |
Actions (login required)
 |
View Item |
