Wahab, S U (2008) Development and Validation of RP-HPLC Method, HPTLC Method and Uvspectrophotometric Simultaneous Equation Method of Pioglitazone, Glimepiride and Metformin In Combined Tablet Dosage Form”, “UV Spectrophotometric Simultaneous Equation Method, UV Spectrophotometric Absorbance Ratio Method For Nebivolol and Hydrochlorothiazide, Lumifantrine and Artemether in Combined Tablet Dosage Form. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
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Abstract
The newer antiviral drugs in combined dosage form are selected for the analysis by high performance liquid chromatography method. It should be more accurate, simple, rapid, efficient than other methods of analytical techniques. Since, the combined dosage formulation can not be easily separated by other analytical technique like UV and other titrimetric analysis. So, that I shall select this HPLC for the separation and estimation of newer anti viral combined dosage forms. It will be simple, rapid, efficient and reliable for the analysis of the drugs in combined dosage form.ioglitazone, Glimepiride and Metformin available in combined dosage form were analysed by UV- spectrophotometric simultaneous equation method, reverse phase high performance liquid chromatography and high performance thin layer chromatography. On comparing all the three methods reverse phase high performance liquid chromatography was found to be more accurate, simple and rapid than other two methods. Nebivolol and Hydrochlorothiazide in combined tablet dosage form was estimated using UV spectophotometry employing simultaneous equation method and absorbance ratio method. On comparing both the method absorbance ratio method was found to be more accurate than simultaneous equation method for routine simultaneous estimation of both the drugs. The values of standard deviation and relative standard deviation were found to be satisfactory. Lumifentrine and Artemether available in combined tablet dosage form was also estimated using UV spectophotometry employing simultaneous equation method and absorbance ratio method. On comparing both the method absorbance ratio method was found to be more accurate than simultaneous equation method for routine simultaneous estimation of both the drugs. The values of standard deviation and relative standard deviation were found to be satisfactory.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | RP-HPLC Method; HPTLC Method; Uvspectrophotometric; Pioglitazone; Glimepiride; Metformin; Spectrophotometric Absorbance Ratio Method; Nebivolol; Hydrochlorothiazide; Lumifantrine; Artemether |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 17 Aug 2017 10:29 |
| Last Modified: | 17 Aug 2017 10:29 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2681 |
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