Srinivasan, M (2012) Molecular Design, Synthesis, Charactrization & Biological Evaluation of New Series of Substituted 1, 4 Dihydro Pyridine Derivatives. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
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Abstract
The chemistry and pharmacology of new serious of 1, 4 DHP derivatives have been great interest, because of various biological action. In search for new bioactive molecule, it was thought worthwhile to incorporate some additional semicarbazide & thio-semicarbazide moiety in the 1,4 DHP nucleolus and study their biological activity, the review of literature reveal prompted us to synthesis of substituted 1, 4 DHP derivatives with semicarbazide & thiosemicarbazide side chain and those will screened for anti-diabetic & antimicrobial action. The main focus of this research work was to synthesize new series of 1,4 DHPs and look for their better antibacterial and antifungal activity. The yield of the newly synthesized DHP series were found to be in the range from 36 to 42%. The identification of the structures was ascertained by melting point and TLC. Structure of the synthesized compounds were confirmed and characterized with the help of IR, 1HNMR and mass spectra. The IR data of synthesized new series of 1, 4 DHPs clearly showed the presence of functional groups C-S, C=N, N-H, and aromatic rings. The 1H-NMR data also showed characteristic peaks of NH and Ar H have been confirmed. The current study provides some useful insight into the anti-hyperglycemic potency of new series of 1,4 DHPs in alloxan induced diabetes and antimicrobial activity of wide range of bacteria and fungi. The antibacterial activity of 1,4 DHP derivatives were produced +ve results. In the series of synthesized compounds B1 significant with standard ( G +ve) and compounds A1&C1 were shown greater activity against E. Coli, D1 against proteus. The antifungal activity E1 compound showed superior activity. However, we suggest that further work should be carried out at molecular level to find out the absolute mechanism of action of 1,4 DHPs in experimental diabetes and wide range of micro-organisms.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Molecular Design; Synthesis; Charactrization; Biological Evaluation; Dihydro Pyridine Derivative |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 17 Aug 2017 09:53 |
| Last Modified: | 17 Aug 2017 09:53 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2678 |
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