Sangeetha, M (2008) Development and validation of RP-HPLC method, UV-Spectrophotometric simultaneous equation and absorbance ratio method of ofloxacin and nitazoxanide in combined tablet dosage form. Development and validation of HPTLC method, UVSpectrophotometric simultaneous equation and absorbance ratio method of montelucast and theophylline in combined tablet dosage form. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
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Abstract
Antibacterial drugs namely ofloxacin and nitazoxanide are selected for analysis by UV spectrophotometric method and reverse phase high performance liquid chromatography. It is estimated by simultaneous equation method as the λmax of the drug is dissimilar and their absorbance ratio lies outside the range 0.1 to 2. It is also estimated by Absorbance ratio methods the drugs absorbs at the λmax of the other. Ofloxacin and Nitazoxanide available in combined tablet dosage form were analysed by UV–spectrophotometric simultaneous equation and absorbance ratio method and reverse phase high performance liquid chromatography. On comparing these methods reverse phase high performance liquid chromatography was found to be more accurate, simple, and rapid than UV spectrophotometric\methods. Montelucast and theophylline in combined tablet dosage form was estimated using High performance thin layer chromatography and UVspectophotometry employing simultaneous equation method and absorbance ratio method. On comparing these methods High performance thin layer chromatography was found to be more accurate ,simple and rapid than UV spectrophotometry methods. The next objective is to develop and validate a reverse phase high performance liquid chromatography which would be simple, rapid, efficient and reliable for the analysis of both the drugs in combined dosage form. Antiasthmatic drugs namely Montelucast and Theophylline existing in combined dosage from are selected for analysis by UV spectrophotometric method and High performance thin layer chromatography. In UV both simultaneous equation and absorbance ratio methods are carried out as the drugs absorbs at the λmax of the other and the ratio of absorbance at any two wavelengths is a constant value independent of concentration or path length.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | RP-HPLC method; UV-Spectrophotometric; loxacin; Nitazoxanide; HPTLC method; Montelucast; Theophylline; |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 17 Aug 2017 09:46 |
| Last Modified: | 17 Aug 2017 09:46 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2677 |
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