Ramachandran, S (2010) Synthesis and Evaluation of Anti Microbial, Analgesic and Ulcerogenic Activities of Some Novel Isatin Schiff and Mannich Bases Substituted with Ciprofloxacin. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
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Abstract
This present study to synthesis some Novel Schiff and Mannich bases of isatin derivatives and screened for its Anti Microbial, Analgesic and Ulcerogenic activities. Schiff Bases can be prepared by using p-Nitro aniline, PABA, p-Bromo aniline and Sulphanilamide. Mannich base can be prepared by using Ciprofloxacin. Novel Schiff’s and Mannich Bases of Isatin Derivatives were synthesized by a 2 step process. The Melting points were found for the synthesized compounds and are uncorrected. The purity of the synthesized compounds were analysed by Thin Layer Chromatography methods. The structures of the synthesized compounds has been elucidated by Infrared and Nuclear Magnetic Resonance Spectroscopy. The Anti Microbial activity of the synthesized compounds were screened by Cup and Plate Method against Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Klebsilla aerogenes and the fungi Candida albicans. All the Compounds Showed maximum activity against Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, and showed Considerable activity against Klebsilla aerogenes and the fungi Candida albicans. Based on the results, it become evident that the attachment of various groups like p-Nitro aniline, PABA, p-Bromo aniline and Sulphanilamide to isatin nucleus along with Ciprofloxacin exhibit greater anti bacterial activity when compared to standard drug Ciprofloxacin. The analgesic activity of the synthesized compounds (5mg/kg) were screened by Acetic Acid Induced Writhing method in Albino rats against the standard drug Diclofenac sodium(25mg/kg).
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Ulcerogenic Activities; Isatin Schiff; Mannich Bases; Ciprofloxacin |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 17 Aug 2017 09:36 |
| Last Modified: | 17 Aug 2017 09:36 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2675 |
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