Alaguraj, K (2009) Development and Validation of RP-HPLC Method and Uv – Spectrophotometric Simultaneous Equation Method of Aceclofenac and Diacerein in Combined Dosage form, Development and Validation of RP-HPLC Method and Uv- Spectrophotometric Simultaneous Equation Method of Mosapride and Pantoprazole in Combined Dosage Form. Development and Validation of RP-HPLC Method and Uv-Specrophotometric Simultaneous Equation Method of Mosapride and Pantoprazole in Combined Dosage Form. Masters thesis, Madurai Medical College, Madurai.
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Abstract
The present studies is the combination of an Anti-inflammatory drug ACECLOFENAC and an Anti-arthritic drug DIACEREIN are selected for analysis by UV spectrophotometric method and reverse phase high performance liquid chromatography. It is estimated by simultaneous equation method as the λmax of the drugs are dissimilar and their absorbance ratio lies outside the range 0.1 to 2. The next objective is to develop and validate a reverse phase high performance liquid chromatography which would be simple, rapid, efficient and reliable for the analysis of both the drugs in combined dosage form. The combination of Gastroprokinetic agent MOSAPRIDE and Proton pump inhibitor PANTOPRAZOLE are selected for analysis by UV spectrophotometric method and reverse phase high performance liquid chromatography. It is estimated by simultaneous equation method as the λmax of the drugs are dissimilar and their absorbance ratio lies outside the range 0.1 to 2. The next objective is to develop and validate a reverse phase high performance liquid chromatography which would be simple, rapid, efficient and reliable for the analysis of both the drugs in combined dosage form. Aceclofenac and Diacerein available in combined dosage form were analysed by UV–spectrophotometric simultaneous equation method and reverse phase high performance liquid chromatography. On comparing both the methods reverse phase high performance liquid chromatography was found to be more accurate, simple, and rapid than simultaneous equation method. The values of standard deviation and relative standard deviation were found to be satisfactory. . Mosapride and Pantoprazole available in combined dosage form were analysed by UV–spectrophotometric simultaneous equation method and reverse phase high performance liquid chromatography. On comparing both the methods reverse phase high performance liquid chromatography was found to be more accurate, simple, and rapid than simultaneous equation method.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | RP-HPLC Method; Uv-Specrophotometric; Mosapride; Pantoprazole; ACECLOFENAC |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 17 Aug 2017 07:50 |
| Last Modified: | 17 Aug 2017 07:50 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2670 |
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