Sheeja Devi, K (2012) Synthesis, Characterization and Biological Evaluation of Novel 1-(3- chloro-2-Oxo-4-Phenylazetidin-1-Yl)-3-(2-Oxo-2-(10h-Phenothiazin-10- Yl)Ethyl)Urea and Thiourea Derivatives. Masters thesis, KMCH College of Pharmacy, Coimbatore.
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Abstract
The present works discus to Phenothiazine and its derivatives reported to possess antipsychotic, antiemetic, antihistamine, antiinflammatory, anthelmintic, antitubercular, antimicrobial, antitumour, antiparkinsonism and anticancer agents. A slight variation in the substitution pattern on the phenothiazine nucleus often resulted in a marked difference in activities and therefore phenothiazines with various substituents are being synthesized and tested for various activities in search of better medicinal agents. Azetidin-2-ones also reported to possess wide therapeutic activity viz. sedative, hypnotics, anticonvulsant, antimicrobial, antitubercular, antidiabetic, anti-inflammatory, analgesic activity, anticancer and antiparkinsonism activities. An attempt was made to synthesize some new congeners by linking azetidinones with phenothiazine pharmacophore to evaluate their possible synergic activity as there were no reports on phenothiazine derivatives containing azetidinone moiety. β-lactam ring connected to ureido linkage possess significant antitubercular activity and tricyclic compounds containing NH and thio group with rigid side chain reported to possess significant antimicrobial, antioxidant and anticancer activity. With this background, a series novel phenothiazine derivatives flanked with azetidinones were synthesized and evaluated for in vitro antimicrobial, antitubercular, antioxidant and anticancer activity. The objectives of the present work are to: synthesize various substituted phenothiazine derivatives, characterize the synthesized compounds using FT-IR, 1H-NMR and mass spectroscopy, carry out in vitro antimicrobial, antitubercular, antioxidant and anticancer evaluation of the synthesized derivatives and explain the possible SAR of the synthesized derivatives
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Phenothiazine; Antipsychotic; Antiemetic; Antihistamine; antiinflammatory; antitubercular; antimicrobial; antitumour; antiparkinsonism; anticancer agents |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 17 Aug 2017 07:32 |
| Last Modified: | 12 Oct 2017 03:03 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2666 |
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