Shanmugarajan, R S (2012) Design, Synthesis and Anticancer Screening of Novel Piperidine ydroxamate as HDAC Inhibitors. Masters thesis, KMCH College of Pharmacy, Coimbatore.
|
Text
2602114shanmugarajanrs.pdf Download (3MB) | Preview |
Abstract
Thirteen compounds were synthesized with piperidine in linker region and hydroxamate as Zinc Binding Group (ZBG). They were screened against (HeLa) human cervical cancer cell-line. Of those, compound 3l (N-hydroxy-1-{[(2E)-2-(2-hydroxybenzylidene) hydrazinyl] carbonothioyl} piperidine-4-carboxamide) was found a lead compound with promising IC50 value of 5.83nM. Further the lead compound would be evaluated against a panel of cancer cell lines and establish its possible mechanism through enzyme inhibition assay.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Synthesis; Anticancer Screening; Novel Piperidine ydroxamate; HDAC Inhibitors |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 17 Aug 2017 07:24 |
| Last Modified: | 12 Oct 2017 03:00 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2665 |
Actions (login required)
 |
View Item |
