Bharathi, D (2010) Synthesis, Characterization and Invitro Anti Inflammatory and Anthelmintic Activities Of 1,3,4-Oxadiazole Derivatives. Masters thesis, Vel’s College of Pharmacy, Chennai.
|
Text
2602060bharathid.pdf Download (1MB) | Preview |
Abstract
The present work deals Molecular modification of simple and complex chemical entities may lead to biological active compounds. Different types of approaches are made to derive such compounds which exhibit selective pharmacological activity. 1, 3, 4 oxadiazole derivatives show potent anti-inflammatory and anthelmintic activities. This research work was oriented towards the finding of derivatives of 1, 3, 4 oxadiazole with anti inflammatory and anthelmintic activities. The different substituted aldehyde derivatives were synthesized by condensation reactions. Seven compounds have been synthesized and all the compounds were labeled 1A-1G. Using different analytical techniques, namely, elemental analysis, IR, 1HNMR and Mass spectroscopical studies the structure of the different substituted 1, 3, 4 oxadiazole derivatives were confirmed. The newly synthesized 1, 3, 4 oxadiazole derivatives were evaluated for their invitro anti-inflammatory by membrane stabilization method. All the synthesized compounds sho wed anti inflammatory activity. Out of all the synthesized compounds 1A and 1B and 1E showed significant anti inflammatory activity. All the other compound shows moderate anti inflammatory activity when compared with that of standard diclofenac. The literature shows that the compounds having methoxy, nitro, hydroxyl groups possess significant anti inflammatory activity33. The synthetic compounds 1A, 1B, 1E possess OCH3, OH, nitro group in its structure. So the anthelmintic activity may be due to the presence of the respective functional groups as evidence in literature. The anthelmintic activity was carried out using two species of earth worm. The synthesized compounds show good anthelmintic activity out of all the synthesized compounds. Compound 1C and 1E showed good anthelmintic property. The activity may be due to the presence of methyl and nitro group in the compound which has been proved in earlier reports12.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Synthesis; Characterization; Invitro Anti Inflammatory; Anthelmintic Activities;1,3,4-Oxadiazole Derivatives |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 17 Aug 2017 06:11 |
| Last Modified: | 17 Aug 2017 06:11 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2650 |
Actions (login required)
 |
View Item |
