Granulosa Cell Tumour Clinico Pathological Study

Jeyalakshmi Devi, N (2007) Granulosa Cell Tumour Clinico Pathological Study. Masters thesis, Madras Medical College, Chennai.

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Ovarian malignancies are the second most common malignancies of the female genital tract. They are the leading cause of death from gynaecological malignancies and constitute 5 to 6% of all cancers in women23. Sex cord stromal tumors account for approximately less than 5% of all primary ovarian tumours. Granulosa cell tumors [GCT] constitute the most common malignant tumors among the sex cord stromal tumors23. They are slow growing, of low malignant potential with a well known predilection to spread beyond the ovary and recur or metastasize after complete removal3. Recurrences are often delayed with intervals between the resection and recurrence or metastasis extending upto three decades32. Two different types of GCTs have been defined based on clinical presentation and histologic characteristics, the juvenile and the adult forms7. The adult GCTs account for 1 to 2% of all ovarian tumors and 95% of all granulosa cell tumors occurring often in menopausal and post menopausal women with peak age incidence between 50 and 55 years33. There are many factors of prognostic significance including the stage at the time of presentation, age, tumor size and histologic parameters. Also, patients with residual disease after surgery might have a poor prognosis23. Surgical intervention is the accepted treatment13. Radiotherapy could play some role in advanced or recurrent disease with minimal residual tumour after operative debulking17. Chemotherapy appears advisable in recurrences or metastases13. This study is based on clinico pathological correlations of 30 cases of granulosa cell tumours (GCT) of the ovary. The plan of the study was to correlate the clinical presentation with the stage of the disease; analyse the various histo morphological patterns and correlate them with the stage; to highlight the utilitarian value of Immuno histochemistry in sexcord stromal tumors.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Granulosa Cell; Tumour Clinico Pathological Study
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 22 Jun 2017 11:10
Last Modified: 22 Jun 2017 11:28

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