Synthesis, Characterization and In-Vitro Anti-Oxidant Activity of Some 1,4-Dihydropyridines and their Mannich Bases.

Arumuganavamani, K (2010) Synthesis, Characterization and In-Vitro Anti-Oxidant Activity of Some 1,4-Dihydropyridines and their Mannich Bases. Masters thesis, Vel’s College of Pharmacy, Chennai.


Download (976kB) | Preview


This studie deals Dihydropyridine have already proven to have variety of pharmacological activities like analgesic, anti-inflammatory, anti-fungal, anti-bacterial, anti-oxidant, anticonvulsant, anti-hypertensive, anti-ulcer, calcium channel antagonist, anti-tumor activity and many more activities. Therefore, based on the previously reported information concerning 1,4.-dihydro pyridine derivatives, I have planned to synthesize some new 1,4dihydro pyridine derivatives with different aldehyde with more biological and chemotherapeutic efficacy as compared to some previously reported dihydro pyridine derivatives with good yield. So an attempt was made to synthesize dihydro pyridine derivatives and prove their anti-oxidant and anti-microbial activities. The current study contains the following Synthesis of 1,4-dihydropyridine derivatives. Synthesis of mannich base of 1, 4- dihydropyridine derivatives. Characterization of synthesised compounds. Screening for Biological Activity Anti-oxidant activity and Anti-microbial. Molecular modification of simple and complex chemical entities may lead to biological active compounds. Different types of approaches are made to derive such compounds which exhibit selective pharmacological activity. Pyridine and their related compounds exhibited potent antioxidant and antimicrobial activity. This research work was oriented towards the finding of newly 1, 4-dihydro pyridine derivatives with antioxidant and anti microbial activities. The different substitution of some 1, 4- dihydro pyridine was synthesized by aromatic aldehydes and ethyl acetoacetate followed by condensation reactions. Ten compounds have been synthesized and all the compounds were tabulated. Using different analytical techniques, elemental analysis, IR 1HNMR and mass spectroscopes. The results of this analysis showed that the expected different substituted some dihydro pyridine derivative were prepared. The newly synthesized some dihydro pyridine derivatives were evaluated for their antioxidant and antimicrobial activity. The synthesized compounds 1e,1c,2d,2e showed effective antioxidant activity, also all the compound expect compound 1d.2b,2c was found to exhibit good antimicrobial activity . This clearly indicates that new dihydro pyridine derivatives can be effectively synthesized by the method mentioned in this study and these compounds exhibited significant antimicrobial and anti oxidant activities.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Synthesis; Characterization; In-Vitro; Anti-Oxidant Activity; 1,4-Dihydropyridines; Mannich Bases
Subjects: PHARMACY > Pharmaceutical Chemistry
Depositing User: Ravindran C
Date Deposited: 17 Aug 2017 06:06
Last Modified: 17 Aug 2017 06:06

Actions (login required)

View Item View Item