Bijosh, K (2009) Synthesis of Certain Schiff's Bases of Cyano Pyrans, Carboethoxy Pyrans and Evaluation of Their Antimicrobial Activities. Masters thesis, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore.
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Abstract
The Present studies is antimicrobial agents are the most commonly used and misused drugs. The main consequence of the widespread use of antimicrobial agents leads to the emergence of antibiotic resistant pathogens. This situation fueling an ever increasing needs for new drugs. Objectives: To synthesize new derivatives and evaluating their possible antimicrobial activity, To study the minimum inhibitory concentration of the highly active compounds, To synthesis highly potent, less toxic compounds, To remove untoward side effects and to prevent development of resistance by infectious microorganisms. Aim: From the literature survey, six membered heterocyclic compounds containing one oxygen atom such as 4H-pyran or 4H-pyrone constitute an important class of various natural and synthetic products which possess antibacterial, antifungal, antioxidant, anti-HIV and anti-tumor activity. From the literature review, it was found that various heterocyclic rings and substituted phenyl groups in the pyran ring shows various biological activities. It was also reveals that schiff's bases show different biological activities. In the light of these observations, the purpose of work is to synthesize cyano pyrans, carboethoxy pyrans and it's Schiff's bases through appropriate synthetic routes and to screen their biological activity. All the newly synthesized compounds were found to be sensitive, moderately sensitive against gram positive organisms. Among the newly synthesized compounds FCP1S, FCP4S, DCP1S, DP1S, DP3S were found to be sensitive at concentration of 1000 mcg/disc against staphylococcus aureus. The compounds FCP3S, DCP3S, DCP5S were found to be sensitive at concentration of 500 mcg/disc against Staphylococcus aureus. All the other compounds were moderately sensitive. Among the newly synthesized compounds FCP4S DCP2S, DP1S, DP3S, DP4S, were found to be sensitive at 1000 mcg/disc against Bacillus subtilis. The synthesized compounds FCP3S, DCP3S, DCP4S, DP2S were found to be sensitive at concentration of 500 mcg/disc against Bacillus subtilis. All the other compounds were moderately sensitive. The compound FCP1S were found to be moderately sensitive against pseudomonas aeruginosa. All the other compounds were not active against Pseudomonas aeruginosa and proteus vulgaris. All the newly synthesized compounds were not active against Candida albicans, Aspergillus niger. From the above observation, it was concluded that various derivatives of carboethoxy pyran and cyano pyran are one of the milestone in the research area. In the present work, all the compounds were active against gram positive bacteria. This work may encourage to do further studies on pyran moiety.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Schiff's;of Cyano Pyrans; Carboethoxy Pyrans; Antimicrobial Activities; Pseudomonas aeruginosa; Aspergillus niger |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 17 Aug 2017 05:50 |
| Last Modified: | 17 Aug 2017 05:50 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2646 |
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