Jegadheeswaran, M (2012) Synthesis and Pharmacological Evaluation of Some New Entities of Bis Indole Substituted Coumarin Derivatives. Masters thesis, K M College of Pharmacy, Madurai.
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Abstract
The present studies is coumarins are the compounds which posses a range of pharmacological activity like anti-HIV, antimicrobial, anticancer and anticoagulant. These pharmacological activities of coumarins have been revealed from literature review. Literatures were also helpful to relate the coumarin and their novel derivatives called Bisindole substituted coumarins for their Antihyperlipidemic activity. So the aim the present study could be divided as follows, Synthesis of some new chemical entities of bisindole substituted coumarins having different groups. Purification and characterization of the synthesised compounds based on their physical properties. Characterization of the compounds based on the spectral data to elucidate their nature. Evaluation of these compounds to check their Anti-hyperlipidemic potential. From the physical characteristics and spectral data of compound S1 – S6 showed that the synthesised compounds were our expected substituted compounds. So these were selected to study their anti-hyperlipidemic potential. So it was concluded that synthetic reactions were completed and yielded our final compounds. Pharmacological Study: Hyperlipidemia is considered to be major risk factor for the premature atherosclerosis and essentially the cholesterol in atherosclerotic plaque is derived from that of circulatory cholesterol. The antihyperlipidemic effect of various synthetic drugs of bisindole substituted coumarin could be considered as a possible therapeutic value.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Indole; Coumarin; synthesised compounds; Antihyperlipidemic activity; Hyperlipidemia |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 17 Aug 2017 05:31 |
| Last Modified: | 17 Aug 2017 05:31 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2643 |
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