Swathylakshmi, N (2012) Development of Analytical Methods for The Determination of Nitazoxanide in Bulk Drug and its Pharmaceutical Formulation. Masters thesis, K M College of Pharmacy, Madurai.
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Abstract
The present study is to develop good analytical methods, having good accuracy and cost effectiveness for the determination of nitazoxanide in bulk drug and its pharmaceutical formulations. The present work deals with the determination of three spectrophotometric methods. First method is based on the formation of Schiff’s base, Second method is based on diazotization coupling method, Third method is based on a simple spectrophotometric method, Fourth method is Reverse-Phase High Performance Liquid Chromatography. Nitazoxanide49 is used for the treatment of diarrhea caused by Giardia lambia /intestinalis or Cryptosporidium parvum. This novel agent has a broad spectrum of activity against many other gastrointestinal pathogens, including bacteria, round worms, flat worms and flukes. Nitazoxanide is used in many areas of the world, especially in Central and South America, as broad-spectrum parasiticidal agents in adults and children. Chemically nitazoxanide is [2-[(5-nitro-1, 3-thiazol-2-yl) carbamoyl] phenyl] ethanoate. Absorption spectroscopy is considered as a versatile technique frequently used in pharmaceutical analysis. Using this technique many pharmaceutical substances can be determined by UV-visible spectrophotometry, HPLC with great precision and accuracy.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Nitazoxanide; spectrophotometric methods; Diazotization coupling method |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ravindran C |
| Date Deposited: | 17 Aug 2017 05:44 |
| Last Modified: | 17 Aug 2017 05:44 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2637 |
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