Mohamed Ismail Muzzamil, M (2011) Development and Evaluation of Sustained Release Bilayer Tablets of Carvedilol. Masters thesis, The Erode College of Pharmacy and Research Institute, Erode.
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Abstract
The present work was carried out to design and evaluate sustained-release bilayer tablets of Carvedilol, an antihypertensive drug. The bilayered sustained release tablets were prepared by wet granulation method using Ethyl Cellulose, Eudragit RSPO, HPMC 4000, lactose, magnesium stearate, talc and sodium starch glycolate. Keeping in view the objectives described above the following plan of work was adopted: - Preparation of standard calibration curve of Carvedilol, Drug-excipients compatibility study by FTIR spectrophotometer, Development of sustained release bilayer tablets using Ethyl cellulose, Eudragit RSPO, HPMC 4000 in three different concentrations by wet granulation method. Evaluation of blend characteristics of prepared granules (Pre-compression parameters) Angle of repose, Determination of bulk density, Determination of tapped density, Compressibility index, Hausner’s Ratio, To perform evaluation parameters like (post-compression parameters) Appearance, Thickness,Hardness,Weight variation test, Friability test,Drug content uniformity,In vitro dissolution studies,Drug release kinetics data analysis and Stability studies of the optimized formulation. The results of the experimental study confirm that the polymer concentration significantly influence the drug release. The tablets of optimized formulation F3 containing HPMC 4000 shown 92.94 % drug release at the end of 12 hrs, this indicates that it can sustain the drug release till the desired time period. While the release rate of the marketed tablet was found to be 95.94%. Results discussed above showed that the tablet of all formulations has acceptable physical parameters. The in vitro release of all the formulations which was subjected to pharmacokinetic data analysis and found that formulations F3 follows Fickian’s model as the best fitted model to the release profile of the formulations.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Bilayer Tablets; Carvedilol; Pharmacokinetic data analysis; Fickian’s model |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 11 Aug 2017 05:48 |
| Last Modified: | 11 Aug 2017 05:48 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2626 |
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