Peddiraja, Nagasai Ramesh (2012) Method Development and Validation for the Estimation of Celecoxib and Diacerein in Pure and Combination by Uv Spectrophotometry and Rp-Hplc. Masters thesis, Adhiparasakthi College of Pharmacy, Melmaruvathur.
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Abstract
The present study contains CELECOXIB and DIACEREIN in solid oral dosage forms, recently this combination of the drugs introduced into market. In the view of the literature cited for the quantification of CELECOXIB and DIACEREIN it was felt that a rapid and accurate method for estimation of CELECOXIB and DIACEREIN individually and in combination with other drugs was available, but no method is available in combined dosage form. The present work is aimed to develop a method for estimation of the drugs in combined capsule dosage form. For UV method, find the drugs solubility in various solvents, to determine maximum absorbance and overlaid termining the standard absorbance for all selected wavelength for each drugs, development of simple, precise, accurate and sensitive Simultaneous equations method, Area under curve method using (Simultaneous equation), Derivative method, in the specified range, Validation of development as per ICH guidelines 27. Diacerein is chemically 9, 10-dihydro-4, 5-dihydroxy-9, 10-dioxo-2-anthranoic acid diacetate. It is an anti rheumatic and used in the treatment of osteoarthritis and chronic inflammatory arthritis. Literature survey reveals that there is no analytical method reported for Simultaneous estimation of Celecoxib and Diacerein in pharmaceutical dosage form. So the present study aims to develop a newer, rapid, accurate and precise analytical method for the Simultaneous estimation of Celecoxib and Diacerein in the formulation of OSTIGARD®. The proposed analytical methods are simple, economical, rapid, sensitive, reproducible and accurate for the simultaneous estimation of Celecoxib and Diacerein. Thus the studies findings would be helpful to the analytical chemists to apply the analytical methods for the routine analysis of the analyte in pharmaceutical dosage forms after their approval from FDA.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Celecoxib; Diacerein; Uv Spectrophotometry; Rp-Hplc |
| Subjects: | PHARMACY > Pharmaceutical Analysis |
| Depositing User: | Ravindran C |
| Date Deposited: | 09 Aug 2017 06:28 |
| Last Modified: | 09 Aug 2017 11:14 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2598 |
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