Appala Raju, Veesam (2011) Formulation and Evaluation of Sustained Release Cyclobenzaprine Hydrochloride Capsules. Masters thesis, The Erode College of Pharmacy and Research Institute, Erode.
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Abstract
The present study was to develop a sustained release formulation of Cyclobenzaprine hydrochloride pellets using powder layering technique. The drug release profile of the test product was to mapped against innovator product. The concept of drug delivery has been explored for the delivery of drugs for prolonged period of time for the past few years. This type of drug delivery has proved to provide a solution to several problems encountered in the repeated administration of such drugs. Utilizing the concept of incorporating drug into the polymer matrices and extend the drug release for prolong period of time, an attempt was made to design and evaluate sustained release pellets of Cyclobenzaprine hydrochloride. To formulate a drug delivery system, which provided a sustained release of the drug that maintained the plasma drug concentration above the MEC for an extended period of 16 hours. The dosing frequency was reduced by formulate into single capsule per day. Even though in market Cyclobenzaprine hydrochloride tablets were available, this work was objected to formulate pellets because of pellets are having good flow properties and high degree of flexibility in the design and development of formulation. Finally to provide the sustained drug delivery system which increases the patient compliance, effectiveness of therapy, reduces the chances of adverse effect and hyper sensitivity of reaction by maintaining the plasma drug concentration at the same level with in therapeutic range for the required period of time. To formulate a drug delivery system, which provided a sustained release of the drug that maintained the plasma drug concentration above the MEC for an extended period of 16 hours. The dosing frequency was reduced by formulate into single capsule per day, even though in market Cyclobenzaprine hydrochloride tablets were available, this work was objected to formulate pellets because of pellets are having good flow properties and high degree of flexibility in the design and development of formulation. Finally to provide the sustained drug delivery system which increases the patient compliance, effectiveness of therapy, reduces the chances of adverse effect and hyper sensitivity of reaction by maintaining the plasma drug concentration at the same level with in therapeutic range for the required period of time.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Cyclobenzaprine; Hydrochloride Capsules |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 11 Aug 2017 05:21 |
| Last Modified: | 11 Aug 2017 05:21 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2589 |
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