Seral Kannan, M (2011) Outcome of graft function with reference to cold ischaemia time in cadaver renal transplant. Masters thesis, Stanley Medical College, Chennai.
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Abstract
INTRODUCTION : The population of India exceeds one billion and is projected to become the major reservoir of chronic diseases like diabetes and hypertension. With 25–40% of these subjects likely to develop ESRD the burden will rise. However, in the absence of any registry, data on incidence of ESRD in India do not exist. A figure of 100 per million population (pmp) per year is often cited, based on estimates from rest of the world, tertiary care center data, and collective experience of experienced Nephrologists39,40,41 Further, it has been estimated that less than 10% of all Indian ESRD patients receive any meaningful renal replacement therapy (RRT). AIM OF THE STUDY : To study the outcome of graft function with reference to cold ischaemia time in cadaver renal transplant prospectively. MATERIALS AND METHODS : All cadaver renal transplants being carried out in Govt Stanley Medical College and Hospital are prospectively studied to assess the impact of variability in cold ischaemia on graft function in renal transplant recipient patients. Period of Study: October 2008 to April 2011. Inclusion criteria: All cadaver transplants first or second. Criteria for Taking Up For Cadaver Transplant: Patients with irreversible renal failure, Patients in cadaver waiting list, Dialysis dependent patients, Patients under the age of 50 years, Second Transplant patients, ABO compatible patients. Exclusion criteria: Live related renal transplant, Live unrelated renal transplant, Non heart beating cadaver renal transplant, Cadavers of less than 6 years, Cadavers with creatinine of more than 2, Cadavers with hypertension and Diabetics. Conclusion : The present study is limited as a result of failure to accurately assess renal core temperature and absence of continuous hypothermic machine perfusion which gives better and predictable perfusion than flushing the kidney with cold perfusion fluid and storing in hypothermic ice. Despite these limitations, present analysis is important as it clearly shows Cold ischaemia time is the most significant risk factor for the development of DGF and its effect appears to be continuous. Sharing of cadaveric kidneys at national level improves tissue matching, but often lengthens the cold ischemia time (CIT).
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | graft function ; cold ischaemia time ; cadaver ; renal transplant ; Outcome. |
| Subjects: | MEDICAL > Urology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 09 Aug 2017 02:42 |
| Last Modified: | 09 Aug 2017 02:42 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2564 |
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