Ragavan, K (2015) A Study of impact of admission mean platelet volume on the efficacy of thrombolysis in st elevation myocardial infarction. Masters thesis, Madras Medical College, Chennai.
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Abstract
The role of platelets in pathogenesis of myocardial infarction is well established. Larger metabolically and enzymatically platelets are released during atherosclerotic plaque rupture. Reactivity and size of the platelets are measured by mean platelet volume and it can be related to the burden of thrombus measured by post thrombolysis TIMI flow. METHODS: Data from Institute of internal medicine and Department of cardiology, Madras medical college, Rajiv Gandhi Government General Hospital were analysed by measuring mean platelet volume on presentation and its relation to post thrombolysis TIMI flow. Patients were divided into two groups having mean platelet volume 9.5 as target. Evaluated by Pearson chi square test. RESULTS: In our study out of 40 patients most of the patients were in the age group of 41-60 years(27 patients) and in sex distribution males were in large number (27 patients).Significant correlation obtained between mean platelet volume and infarct size, TIMI flow ,platelet count ,left ventricular systolic function, number of vessels involved. CONCLUSIONS: Successfulness of thrombolysis was inversely proportional to admission mean platelet volume. Infarct related artery patency and TIMI flow were inversely proportional to admission mean platelet volume. Platelet count was inversely proportional to admission MPV. Total count has correlated with infarct size.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Myocardial Infarction; TIMI Flow; Mean Platelet Volume |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Punitha K |
| Date Deposited: | 07 Aug 2017 11:08 |
| Last Modified: | 09 Aug 2017 03:06 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/2519 |
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